Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
USP5 regulates ferroptosis in colorectal cancer by targeting the YBX3/SLC7A11 axis through lysosomal degradation

Haowen Qiu
Yi Liu
Guoqing Li
ResearchOpen Access10 Nov 2025
Cell Death & Disease

Volume: 16, P: 1-16
Programming chain-growth copolymerization of DNA hairpin tiles for in-vitro hierarchical supramolecular organization

Formation of biological filaments via intracellular supramolecular polymerization of proteins occurs under programmable and spatiotemporal control to maintain integrity. Here the authors devise a bioinspired isothermal chain-growth approach to programmably copolymerize DNA hairpin tiles into 1D nanofilaments.

Honglu Zhang
Yu Wang
Chunhai Fan
ResearchOpen Access01 Mar 2019
Nature Communications

Volume: 10, P: 1-11
ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription

Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network. These HERVH RNAs can partition into BRD4 foci, affecting BRD4-dependent transcription. Suppression of HERVH in colorectal cancer cells and patient-derived organoids impairs tumor growth.

Chunhong Yu
Xiaoyun Lei
Kai Yuan
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-16
Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.

Zhongyuan Bao
Yinlong Liu
Jing Ji
ResearchOpen Access09 Jul 2021
Nature Communications

Volume: 12, P: 1-19
DNA origami-based shape IDs for single-molecule nanomechanical genotyping

Atomic force microscopy allows for the imaging of molecules at a nanometre resolution. Here the authors combine AFM with self-assembling DNA origami structures to detect single-nucleotide polymorphisms and determine haplotypes.

Honglu Zhang
Jie Chao
Chunhai Fan
ResearchOpen Access06 Apr 2017
Nature Communications

Volume: 8, P: 1-7
Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials

Chao Lin
Hongquan He
Ning Liu
ResearchOpen Access25 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Prediction of peak particle velocity using hybrid random forest approach

Yu Yan
Jiwei Guo
Honglu Fei
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-27
Dissolution, solvation and diffusion in low-temperature zinc electrolyte design

Aqueous electrolytes can suffer from freezing, impeded ion migration and sluggish desolvation kinetics at low temperatures. This Review describes the dissolution, solvation and diffusion chemistry of zinc salts in cold-resistant electrolyte formulations for Zn batteries that promise energy storage applications.

Yang Dong
Honglu Hu
Fangyi Cheng
Reviews08 Jan 2025
Nature Reviews Chemistry

Volume: 9, P: 102-117
Research on the construction method of high-speed railway tunnel in sandy loess and fine sand composite strata

Dianhong Xu
Bingzhou Yan
Xu Wang
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Investigation into the temporal impacts of drought on vegetation dynamics in China during 2000 to 2022

Yutian Du
Subing Lv
Honglu Zhang
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Analysis of influencing factors and paths of synergistic development of water resources-economic society-ecological environment based on DIM modeling

Suming Ren
Fuqiang Wang
Lanbo Cui
ResearchOpen Access18 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Programming DNA origami assembly for shape-resolved nanomechanical imaging labels

This protocol describes the design of DNA origami-based shape IDs and their applications in the identification of single-nucleotide polymorphisms using atomic force microscopy.

Jie Chao
Honglu Zhang
Chunhai Fan
Protocols09 Jul 2018
Nature Protocols

Volume: 13, P: 1569-1585
Deep-gray nuclei susceptibility-weighted imaging filtered phase shift in patients with Wilson’s disease

Xue Bai
Guangbin Wang
Lingfei Guo
Research12 Dec 2013
Pediatric Research

Volume: 75, P: 436-442
Lifestyle factors, glycemic traits, and lipoprotein traits and risk of liver cancer: a Mendelian randomization analysis

Honglu Zhang
Jiyong Liu
ResearchOpen Access12 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1

Zong Miao
Wei Tian
Jing Ji
ResearchOpen Access13 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-14
Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling

Yiming Tu
Lei Xu
Jing Ji
Research25 Mar 2022
Oncogene

Volume: 41, P: 2597-2608

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