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Showing 1–4 of 4 results

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Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity

Chen et al. show that redox signals activate ADAR1 to fix faulty RNA pieces during DNA copying, ensuring smooth replication and protecting genome stability.

Bin Chen
Guangchao Sun
Zhenkun Lou
Research08 Jan 2026
Nature Structural & Molecular Biology

P: 1-11
KCTD10 is a sensor for co-directional transcription–replication conflicts

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Jake A. Kloeber
Bin Chen
Zhenkun Lou
ResearchOpen Access08 Oct 2025
Nature

Volume: 648, P: 210-219
Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation

Hongjin Qu
Lei Liu
Jianming Cai
ResearchOpen Access15 Apr 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-17
FSP1⁺ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells

Lina Sun
Chenming Sun
Yong Zhao
ResearchOpen Access08 Oct 2015
Scientific Reports

Volume: 5, P: 1-16