Nature Search

Population-scale sequencing resolves determinants of persistent EBV DNA

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous disease associations.

Sherry S. Nyeo
Erin M. Cumming
Caleb A. Lareau
ResearchOpen Access28 Jan 2026
Nature

Volume: 650, P: 664-672
Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Chu-Yi Zhang
Miao Li
Ming Li
Research25 Nov 2025
Nature Neuroscience

Volume: 29, P: 293-305
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy

Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances CAR T cell activity against low-antigen-density tumors.

Maria Caterina Rotiroti
Aidan M. Tousley
Robbie G. Majzner
ResearchOpen Access23 Oct 2025
Nature Cancer

Volume: 6, P: 1940-1954
Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS)

The current use of immune checkpoint inhibitors without chemotherapy on patients with metastatic breast cancer (MBC) has not proven useful. Here this group reports a phase 2 NIMBUS trial evaluating the efficacy/safety of nivolumab + low dose ipilimumab in 30 patients with hypermutated HER2-negative MBC.

Romualdo Barroso-Sousa
Jorge Gomez Tejeda Zanudo
Sara M. Tolaney
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-13
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Alexandre Pellan Cheng
Adam J. Widman
Dan A. Landau
Research11 Apr 2025
Nature Methods

Volume: 22, P: 973-981
Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Rui Xue Zhang
Jason Li
Xiao Yu Wu
Reviews26 Apr 2018
Acta Pharmacologica Sinica

Volume: 39, P: 825-844
Genetic evidence for the “dopamine hypothesis of bipolar disorder”

Chu-Yi Zhang
Xin Cai
Xiao Xiao
Correspondence05 Oct 2022
Molecular Psychiatry

Volume: 28, P: 532-535

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Population-scale sequencing resolves determinants of persistent EBV DNA

Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy

Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS)

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Genetic evidence for the “dopamine hypothesis of bipolar disorder”

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