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Showing 1–9 of 9 results
Advanced filters: Author: Huanzhen Ni Clear advanced filters

  • FcγRIIb captures its ligand and targets it to lysosomal degradation following endocytosis. Here authors design bispecific-antibody-like molecules they call FcγRIIb-targeting chimeras or FcRTACs, to capture antigens with one arm and degrade them via an FcγRIIb-binding second arm to promote the clearance of pathological protein aggregates.

    • Mingjuan Du
    • Na Li
    • Hongkai Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • The development of broadly neutralizing monoclonal antibodies is crucial in the fight against viral infections. Here, using combinatorial library technology, the authors identify 3D1, a monoclonal antibody with potential pan-inhibitory activity against a range of viral families, and provide structural analysis to reveal the basis of the broad cross-reactivity.

    • Lei Yan
    • Fulian Wang
    • Guang Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.

    • Huanzhen Ni
    • Marine Z. C. Hatit
    • James E. Dahlman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Stereochemistry can affect the reactivity and transport properties of small molecules; however, it is unclear whether the stereochemistry of components in a lipid nanoparticle influences its activity in vivo. Now, it has been shown that lipid nanoparticles made with a stereopure component can increase delivery of mRNA. A biological mechanism driving the effect is also proposed.

    • Marine Z. C. Hatit
    • Curtis N. Dobrowolski
    • James E. Dahlman
    Research
    Nature Chemistry
    Volume: 15, P: 508-515

  • Cell heterogeneity might impact the delivery of lipid nanoparticles (LNPs) and efficacy of messenger RNA-based therapies in vivo. Here, the authors propose an approach to measure how various LNPs deliver DNA barcodes and mRNA to cells using single-cell RNA sequencing, providing a correlation between LNP uptake and the expression of specific genes that characterize cellular subtypes.

    • Curtis Dobrowolski
    • Kalina Paunovska
    • James E. Dahlman
    Research
    Nature Nanotechnology
    Volume: 17, P: 871-879

  • The extent to which mRNA delivery, as well as the cellular response to mRNA drug delivery vehicles, is conserved across species in vivo is unknown. Using species-independent DNA barcoding, the authors measure delivery in humanized, primatized and normal mice, and identify a potential mechanism driving species-dependent lipid nanoparticle delivery.

    • Marine Z. C. Hatit
    • Melissa P. Lokugamage
    • James E. Dahlman
    Research
    Nature Nanotechnology
    Volume: 17, P: 310-318