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Showing 1–3 of 3 results
Advanced filters: Author: Huapeng Su Clear advanced filters

  • Glut1-deficiency syndrome is a severe neurodevelopmental disorder characterized by low brain glucose and epileptic seizures. Tanget al. show that in model mice, low Glut1 leads to defects of the brain vasculature, and that AAV9-based gene therapy at pre- or early-symptomatic stages prevents the defects and mitigates disease.

    • Maoxue Tang
    • Guangping Gao
    • Umrao R. Monani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Tough decoy microRNA inhibitor, shown to be the most effective of several designs, is packaged in recombinant adeno-associated virus and used for prolonged microRNA inhibition in living mice. A single injection effectively reduces miR-122 in the liver and serum cholesterol for at least 25 weeks.

    • Jun Xie
    • Stefan L Ameres
    • Guangping Gao
    Research
    Nature Methods
    Volume: 9, P: 403-409

  • Diminished m6A levels contribute to recurrent implantation failure. Mechanistic studies indicate that the Mettl3/Eed/Ythdc1 axis affects endometrial function by modulating histone modification and chromatin accessibility.

    • Xiujuan Hu
    • Jincheng Li
    • Boxian Huang
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14