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Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes

The ambiphilic reactivity of alkyl sulfonyl fluorides in stereoselective cyclopropanation under Pd(II) catalysis is reported. The method provides convenient access to cis-disubstituted cyclopropanes that are otherwise challenging to access. A representative carboxylic acid cyclopropane building block is scaled up to 100 mmol, demonstrating the practicality of this transformation.

Yilin Cao
Warabhorn Rodphon
Keary M. Engle
ResearchOpen Access16 Dec 2025
Nature Synthesis

P: 1-9
Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, the authors report a palladium-catalyzed [3 + 2] (hetero)annulation proceeding in an anti-selective fashion and enabling direct access to these valuable heterocycles with broad reaction scope.

Hui-Qi Ni
Ilia Kevlishvili
Keary M. Engle
ResearchOpen Access22 Dec 2020
Nature Communications

Volume: 11, P: 1-8
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation

Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.

Hai-Liang Zhang
Yi-Qing Guo
Xiao-Feng Zhu
Research17 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1531-1543
Organoid forming potential as complementary parameter for accurate evaluation of breast cancer neoadjuvant therapeutic efficacy

Hai-Shan Ye
Dan Zhou
Jia Liu
Research10 Feb 2024
British Journal of Cancer

Volume: 130, P: 1109-1118
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A

Tong Zhao
Zhi-ruo Zhou
Xu Shen
Research19 Aug 2024
Acta Pharmacologica Sinica

Volume: 46, P: 107-121
Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome

Yan Li
Hui Qi Ng
CongBao Kang
ResearchOpen Access30 Mar 2016
Scientific Reports

Volume: 6, P: 1-10

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Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes

Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation

Organoid forming potential as complementary parameter for accurate evaluation of breast cancer neoadjuvant therapeutic efficacy

Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A

Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome

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