Dang et al. integrate GWAS with functional genomics to analyze 15 common autoimmune diseases, mapping interconnections and differences in target genes, association signals, and the immune cell types in which signals act. They show cell-type-specific signals within loci, prioritize associated genes, and identify shared and distinct functional modules, clarifying regulatory mechanisms.
- Xiao Dang
- Frank Qingyun Wang
- Wanling Yang