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Showing 1–14 of 14 results

Advanced filters: Author: Huifang Deng Clear advanced filters

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages.

Baisheng Li
Aiping Deng
Jing Lu
ResearchOpen Access24 Jan 2022
Nature Communications

Volume: 13, P: 1-9
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway

Zhu and colleagues show that a subpopulation of spleen-derived fibroblasts secrete Gremlin 1, which suppresses chronic myeloid leukemia progression by inducing leukemia stem cell apoptosis through the BMP signaling pathway.

Jinming Wang
Penghui Xu
Helen He Zhu
Research17 Mar 2025
Nature Cancer

Volume: 6, P: 666-681
Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer

Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

Kai Zhang
Kaiyuan Liu
Helen He Zhu
ResearchOpen Access20 Oct 2024
Nature Communications

Volume: 15, P: 1-19
Deciphering the hepatoprotective mechanism of Sarcopyramis nepalensis wall against non-alcoholic fatty liver disease by network pharmacology and experimental validation

Huifang Lai
Chenting Zhu
Xiaoping Wang
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial

Chimeric Antigen Receptor (CAR)-T cells show suboptimal efficacy in Acute Myeloid Leukaemia (AML). Here, the authors show that overexpression of C-JUN improves CAR-T cells efficacy in preclinical models for AML and report preliminary results of a pilot phase I clinical trial.

Shiyu Zuo
Chuo Li
Xiaoming Feng
ResearchOpen Access22 Jul 2024
Nature Communications

Volume: 15, P: 1-20
Stabilizing triplet excited states for ultralong organic phosphorescence

A design rule to synthesize organic molecules with a phosphorescence lifetime longer than 1 second is presented. The molecules form H aggregates that promote the stabilization of triplet excitons and persistent luminescence under ambient conditions.

Zhongfu An
Chao Zheng
Wei Huang
Research06 Apr 2015
Nature Materials

Volume: 14, P: 685-690
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer

Zhu and colleagues identify GREMLIN1 as an FGFR1 ligand that promotes plasticity and castration resistance in prostate cancer through regulation of MAPK signaling, and show that anti-GREMLIN1 antibody therapy synergizes with androgen deprivation.

Chaping Cheng
Jinming Wang
Helen He Zhu
Research27 May 2022
Nature Cancer

Volume: 3, P: 565-580
RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells

Zizhen Wu
Huifang Liu
Jingyu Deng
ResearchOpen Access20 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-11
DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

Weilin Sun
Gang Ma
Jingyu Deng
ResearchOpen Access30 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-12
Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer

Deng Wang
Genyu Du
Helen He Zhu
Research23 Apr 2024
Cell Death & Differentiation

Volume: 31, P: 779-791
USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma

Jin Chen
Deng Ning
Xiaoping Chen
Research16 Nov 2023
Oncogene

Volume: 43, P: 123-135
CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells

Lang He
Shang Wang
Hong Jiang
ResearchOpen Access17 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-13
Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis

Huifang Deng
Brecht Devleesschauwer
Marieke Opsteegh
ResearchOpen Access18 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15

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Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway

Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer

Deciphering the hepatoprotective mechanism of Sarcopyramis nepalensis wall against non-alcoholic fatty liver disease by network pharmacology and experimental validation

C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial

Stabilizing triplet excited states for ultralong organic phosphorescence

Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer

RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer

USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma

CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells

Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis

Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

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