Nature Search

DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models

This study reports DLFea4AMPGen, a peptide design strategy that leverages deep learning to identify and extract key features for the generation of new antimicrobial peptides (AMPs), which allowed for the identification of 12 AMPs with bioactivity.

Han Gao
Feifei Guan
Huoqing Huang
ResearchOpen Access15 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.

Tanlin Wei
Xiaofeng Yang
Hui Li
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 17, P: 1-12
Automated MRI system for clinically significant prostate cancer detection development validation and real-world implementation

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

Hanchang Wu
Fang Liu
Yun Bian
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors

Here, authors show the behavioral function of two transcriptomic GABAergic neuron subtypes in the zona incerta by integrating single-nucleus sequencing, circuit mapping, and optogenetics, advancing our understanding of functional brain organization.

Mengyue Zhu
Jieqiao Peng
Jiadong Chen
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Spontaneous water dissociation on intermetallic electride LaCu_0.67Si_1.33 enhances electrochemical methanization of CO₂

Water dissociation has proven power in tuning the behaviors of electrochemical CO₂ reduction. Here, the authors report the spontaneous water dissociation capability of the intermetallic electride LaCu_0.67Si_1.33 material that enables high rate electrosynthesis of methane from CO₂.

Luming Zhang
Huan Ma
Mingchuan Luo
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-10
Transparent and dynamic network-based risk assessment for development of hepatic encephalopathy

Wang et al at introduce a dynamic, network-based tool to predict the risk of hepatic encephalopathy in patients with cirrhosis. The model integrates expert knowledge with data-driven insights to enable early prediction and risk stratification across diverse patient populations.

Zixing Wang
Suzhen Jiang
Huiying Rao
ResearchOpen Access10 Dec 2025
Communications Medicine

Volume: 6, P: 1-10
The Genome Sequences of 90 Mushrooms

Huiying Li
Surui Wu
Yang Dong
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-5
The dynamic process of hyperfocusing and hyperfiltering in schizophrenia

Hyperfocusing in schizophrenia is accompanied with hyperfiltering of irrelevant information over time.

Jian Li
Bao-liang Zhong
Hui Chen
Research16 Feb 2024
Nature Mental Health

Volume: 2, P: 367-378
C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

The HOPS complex mediates membrane tethering and autophagosome-lysosome fusion. Here, the authors biochemically reconstitute the mammalian HOPS in protoliposomes and propose a model of complex assembly that depends on Rab2 and Rab39A.

Shen Zhang
Mindan Tong
Qing Zhong
ResearchOpen Access11 Oct 2023
Nature Communications

Volume: 14, P: 1-19
Author Correction: The Genome Sequences of 90 Mushrooms

Huiying Li
Surui Wu
Yang Dong
Amendments and CorrectionsOpen Access18 May 2020
Scientific Reports

Volume: 10, P: 1
A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung

Single-cell transcriptomics of human lung tissue from individuals with tuberculosis identifies signatures of inflammation, apoptosis and senescence affecting immune, epithelial and endothelial cells linked with long-term pulmonary impairment.

Guoqiang Sun
Kuan Li
Guang-Hui Liu
Research14 Jul 2025
Nature Microbiology

Volume: 10, P: 2073-2091
Efficacy of pulmonary transplantation of engineered macrophages secreting IL-4 on acute lung injury in C57BL/6J mice

Huiying Liu
Yuan He
Changqing Bai
ResearchOpen Access11 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-10
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

The expression of the stimulator of interferon genes (STING) in liver tissues is associated with the progression of human nonalcoholic fatty liver disease. Specifically, STING-expressing macrophages, in particular, monocyte-derived macrophages, are positively correlated with the degree of liver inflammation and/or fibrosis progression, which appeared to be mediated by the activation of the STING-TBK1 signaling pathway in macrophage.

Xiaoxiao Wang
Huiying Rao
Lai Wei
Research19 Nov 2019
Laboratory Investigation

Volume: 100, P: 542-552
CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy

Huiying Sun
Rui Zhou
Wangjun Liao
ResearchOpen Access14 Jul 2021
Oncogene

Volume: 40, P: 5342-5355
Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Wencheng Zhu
Huiying Chu
Weiwei Yang
Research16 Jan 2023
Cell Research

Volume: 33, P: 245-257
Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

Biao Di
Hongling Jia
Zhicong Yang
ResearchOpen Access03 Oct 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-4
Thermostability improvement of a Talaromyces leycettanus xylanase by rational protein engineering

Xiaoyu Wang
Rui Ma
Huiying Luo
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner

Tong Yu
Yanyan Liu
Hongli Shan
ResearchOpen Access09 Jul 2022
Cell Death Discovery

Volume: 8, P: 1-14
Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice

Changjiao Gan
Wenbo Luo
Huiying Yang
ResearchOpen Access22 Jun 2021
npj Vaccines

Volume: 6, P: 1-10
Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice

Xiaochun Chi
Weiwei Luo
Hongquan Zhang
ResearchOpen Access11 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-16
Correction: Corrigendum: Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency

Canfang Niu
Peilong Yang
Bin Yao
Amendments and CorrectionsOpen Access30 Jun 2017
Scientific Reports

Volume: 7, P: 1
Insight into the cold adaptation and hemicellulose utilization of Cladosporium neopsychrotolerans from genome analysis and biochemical characterization

Rui Ma
Huoqing Huang
Bin Yao
ResearchOpen Access17 Apr 2018
Scientific Reports

Volume: 8, P: 1-14
Probing the role of cation-π interaction in the thermotolerance and catalytic performance of endo-polygalacturonases

Tao Tu
Yeqing Li
Huiying Luo
ResearchOpen Access08 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency

Canfang Niu
Peilong Yang
Bin Yao
ResearchOpen Access10 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
Functional diversity of family 3 β-glucosidases from thermophilic cellulolytic fungus Humicola insolens Y1

Wei Xia
Yingguo Bai
Bin Yao
ResearchOpen Access08 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Gas-assisted microfluidic step-emulsification for generating micron- and submicron-sized droplets

Biao Huang
Xinjin Ge
Zhenzhen Li
ResearchOpen Access10 Jul 2023
Microsystems & Nanoengineering

Volume: 9, P: 1-13
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest

Wenpeng Zhao
Liang Zhang
Zhanxiang Wang
ResearchOpen Access09 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-11
Discovery of Ca²⁺-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray

Aiping Luo
Jianping Kong
Zhihua Liu
Research01 Dec 2003
Oncogene

Volume: 23, P: 1291-1299
Validation of the imatinib-therapy failure model

Xiaoshuai Zhang
Robert Peter Gale
Qian Jiang
Correspondence27 Mar 2023
Leukemia

Volume: 37, P: 1166-1169

Search

DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models

Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells

Automated MRI system for clinically significant prostate cancer detection development validation and real-world implementation

Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors

Spontaneous water dissociation on intermetallic electride LaCu_0.67Si_1.33 enhances electrochemical methanization of CO₂

Transparent and dynamic network-based risk assessment for development of hepatic encephalopathy

The Genome Sequences of 90 Mushrooms

The dynamic process of hyperfocusing and hyperfiltering in schizophrenia

C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

Author Correction: The Genome Sequences of 90 Mushrooms

A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung

Efficacy of pulmonary transplantation of engineered macrophages secreting IL-4 on acute lung injury in C57BL/6J mice

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy

Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

Thermostability improvement of a Talaromyces leycettanus xylanase by rational protein engineering

Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner

Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice

Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice

Correction: Corrigendum: Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency

Insight into the cold adaptation and hemicellulose utilization of Cladosporium neopsychrotolerans from genome analysis and biochemical characterization

Probing the role of cation-π interaction in the thermotolerance and catalytic performance of endo-polygalacturonases

Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency

Functional diversity of family 3 β-glucosidases from thermophilic cellulolytic fungus Humicola insolens Y1

Gas-assisted microfluidic step-emulsification for generating micron- and submicron-sized droplets

The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest

Discovery of Ca²⁺-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray

Validation of the imatinib-therapy failure model

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