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Scientific Reports (14)
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Showing 1–50 of 60 results

Advanced filters: Author: Huiyong Li Clear advanced filters

Author Correction: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Min Li
Xuxiao He
Huiyong Yin
Amendments and Corrections04 Nov 2025
Nature Cancer

Volume: 6, P: 1900
Early detection of urological tumors based on genomic characteristics of cell-free DNA fragments: a multi-center study

Huiyong Zhang
Caihong Huang
Fubo Wang
ResearchOpen Access17 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-11
ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in Parkinson’s disease

Xuan Li
Si-Jia Peng
Yun-Cheng Wu
ResearchOpen Access02 Dec 2025
npj Parkinson's Disease

Volume: 11, P: 1-15
Linker-free PROTACs efficiently induce the degradation of oncoproteins

Linkers are traditionally seen as important for PROTAC activity. Here, the authors demonstrate that linker-free PROTACs can outperform traditional designs, marking a paradigm shift in PROTAC development for targeted protein degradation.

Jianchao Zhang
Congli Chen
Hai Rao
ResearchOpen Access23 May 2025
Nature Communications

Volume: 16, P: 1-15
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma

STING signalling is activated in metastatic cancer cells that exit from an immune-evasive dormant state, blocking their progression and cancer relapse.

Jing Hu
Francisco J. Sánchez-Rivera
Joan Massagué
Research29 Mar 2023
Nature

Volume: 616, P: 806-813
CAFs exosomal circFOXO1 promotes TNBC autophagy and radioresistance via miR-27a-3p/BNIP3 axis

Xueqiong Xun
Huiyong Hu
Jun Ai
ResearchOpen Access10 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers

Weihao Zhang
Jiajie Lin
Zhongyu Xie
ResearchOpen Access23 Dec 2025
Cell Death & Disease

Volume: 16, P: 1-14
7-Dehydrocholesterol dictates ferroptosis sensitivity

7-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and ischaemia–reperfusion injury.

Yaxu Li
Qiao Ran
Ping Wang
Research31 Jan 2024
Nature

Volume: 626, P: 411-418
TNF-α-mediated m⁶A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.

Zhongyu Xie
Wenhui Yu
Huiyong Shen
ResearchOpen Access10 Sept 2021
Nature Communications

Volume: 12, P: 1-14
Retraction Note: Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer

Congling Xu
Xinrui Wang
Ji Zhang
Amendments and Corrections24 Nov 2025
Oncogene

Volume: 44, P: 4916
Methylcobalamin protects against liver failure via engaging gasdermin E

Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here, the authors show that methylcobalamin in base-off conformation coordinates to Cys180 in GSDME to prevent caspase-3/GzmB-GSDME interactions and thereby GSDME-mediated liver failure.

Wanfeng Xu
Yun Wang
Lijuan Cao
ResearchOpen Access31 Jan 2025
Nature Communications

Volume: 16, P: 1-16
The manuring principles in ancient China from the perspective of the San Cai theory

Huiyong Ouyang
Xue Shang
ResearchOpen Access02 Sept 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-14
Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Yin and colleagues show that hepatic aldolase B suppresses hepatocellular carcinoma by controlling tumor metabolic reprogramming through G6PD inhibition.

Min Li
Xuxiao He
Huiyong Yin
Research06 Jul 2020
Nature Cancer

Volume: 1, P: 735-747
Soil microbial and enzymatic signatures decode ancient millet fertilization strategies in Guanzhong arid farmlands

Zhizhen Feng
Xue Shang
Jianqiang Liang
ResearchOpen Access01 Dec 2025
npj Heritage Science

Volume: 13, P: 1-9
KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells

Xin Qi
Jiang Zhou
Jiong Lyu
ResearchOpen Access02 May 2025
Cell Death & Disease

Volume: 16, P: 1-13
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.

Tuoyi Li
Bing Yu
Wei Kong
ResearchOpen Access02 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Chemoproteomic mapping of the glycolytic targetome in cancer cells

A chemoproteomic approach is developed that examines changes in ligand binding-induced accessibility by globally labeling reactive proteinaceous lysines, revealing the cellular targets of glycolytic intermediates.

Yang Tian
Ning Wan
Haiping Hao
Research15 Jun 2023
Nature Chemical Biology

Volume: 19, P: 1480-1491
Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.

Yanan Zhang
Jiancheng Wang
Andy Peng Xiang
ResearchOpen Access06 Sept 2018
Nature Communications

Volume: 9, P: 1-14
Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification

Zhongyu Xie
Wenhui Yu
Huiyong Shen
ResearchOpen Access01 Apr 2022
Experimental & Molecular Medicine

Volume: 54, P: 483-492
Revealing the favorable dissociation pathway of type II kinase inhibitors via enhanced sampling simulations and two-end-state calculations

Huiyong Sun
Sheng Tian
Tingjun Hou
ResearchOpen Access13 Feb 2015
Scientific Reports

Volume: 5, P: 1-8
Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.

Liting Zhai
Lingling Feng
Song Xiang
ResearchOpen Access18 Apr 2016
Nature Communications

Volume: 7, P: 1-11
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming

Xiaojun Xu
Peitao Xu
Jinteng Li
ResearchOpen Access26 Feb 2025
Cellular & Molecular Immunology

Volume: 22, P: 418-436
Elevated TRAF4 expression impaired LPS-induced autophagy in mesenchymal stem cells from ankylosing spondylitis patients

Jinteng Li
Peng Wang
Huiyong Shen
ResearchOpen Access09 Jun 2017
Experimental & Molecular Medicine

Volume: 49, P: e343
Efficient generation of Bessel-Gauss attosecond pulse trains via nonadiabatic phase-matched high-order harmonics

Attosecond EUV Bessel-Gauss beam can now be generated through propagating an annular high harmonic source produced by the interaction of a strong laser with atomic gas.

Mingxuan Li
Xiangyu Tang
Dajun Ding
ResearchOpen Access06 May 2025
Light: Science & Applications

Volume: 14, P: 1-10
Effects of hydrothermal factors and human activities on the vegetation coverage of the Qinghai-Tibet Plateau

Jianxiao Guo
Liang Zhai
Hongwei Li
ResearchOpen Access01 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

Chen-Song Zhang
Simon A. Hawley
Sheng-Cai Lin
Research19 Jul 2017
Nature

Volume: 548, P: 112-116
Experimental archaeological study in China: implications for reconstruction of past manuring and dietary practices indicated by δ¹⁵N values of Setaria italica and Panicum miliaceum

Huiyong Ouyang
Xue Shang
Xiaoqiang Li
ResearchOpen Access15 Feb 2024
Heritage Science

Volume: 12, P: 1-16
Improved Snake Optimization Algorithm for Global Optimization and Engineering Applications

Kaiyuan Zheng
Huiyong Liu
Bopeng Li
ResearchOpen Access25 May 2025
Scientific Reports

Volume: 15, P: 1-48
Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li
Zhongyu Xie
Huiyong Shen
Amendments and CorrectionsOpen Access31 May 2024
Cell Death & Disease

Volume: 15, P: 1-3
Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

Lv et al. associate the gut mycobiota with clinical features and the bacterial microbiota by comparing COVID-19 patients to those infected with H1N1 and healthy controls. They find that gut mycobiota dysbiosis occurs in both COVID-19 patients and those infected with H1N1 and that it does not improve until patients no longer require medical attention, providing insights into a better healthcare guideline.

Longxian Lv
Silan Gu
Lanjuan Li
ResearchOpen Access13 Apr 2021
Communications Biology

Volume: 4, P: 1-11
Blocking the CXCL1-CXCR2 axis enhances the effects of doxorubicin in HCC by remodelling the tumour microenvironment via the NF-κB/IL-1β/CXCL1 signalling pathway

Huiyong Zhao
Sheng Wei
Xiao Cui
ResearchOpen Access10 Apr 2023
Cell Death Discovery

Volume: 9, P: 1-10
Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery

Huiyong Sun
Peichen Pan
Tingjun Hou
ResearchOpen Access22 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis

Xinglang Wang
Yunhui Zhang
Peng Wang
ResearchOpen Access12 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-13
Erratum: Effect of intrathecal papaverine on blood flow and secondary injury in injured cord

T Yong
S Huiyong
W Peng
Amendments and Corrections06 Nov 2008
Spinal Cord

Volume: 46, P: 766
Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis

Jianfan Chen
Xueqing Xu
Fu Xiong
ResearchOpen Access26 Sept 2023
International Journal of Oral Science

Volume: 15, P: 1-13
MiR-150 promotes cellular metastasis in non-small cell lung cancer by targeting FOXO4

Hui Li
Ruoyun Ouyang
Bin Zhang
ResearchOpen Access15 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu
Zhongyu Xie
Huiyong Shen
Amendments and CorrectionsOpen Access26 Jun 2023
Bone Research

Volume: 11, P: 1-4
Analysis of genome and methylation changes in Chinese indigenous chickens over time provides insight into species conservation

Comparisons of genomic and methylomic changes during the conservation of indigenous chicken breeds in China provide insight into conservation programmes for these breeds and their adaptations to unique environments.

Tao Zeng
Jianmei Yin
Lizhi Lu
ResearchOpen Access12 Sept 2022
Communications Biology

Volume: 5, P: 1-11
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Guiwen Ye
Jinteng Li
Huiyong Shen
ResearchOpen Access01 Aug 2023
Experimental & Molecular Medicine

Volume: 55, P: 1743-1756
Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu
Zhongyu Xie
Huiyong Shen
ResearchOpen Access07 Jun 2023
Bone Research

Volume: 11, P: 1-16
The N⁶-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6

Zhaofeng Li
Peng Wang
Huiyong Shen
ResearchOpen Access04 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-16
TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

Jinteng Li
Peng Wang
Huiyong Shen
ResearchOpen Access10 May 2019
Cell Death & Differentiation

Volume: 26, P: 2652-2666
Mouse models for human hyperuricaemia: a critical review

Hyperuricaemia is a risk factor for gout, and mouse models of this condition can help dissect the underlying regulatory mechanisms. However, these models come with both advantages and disadvantages, and interpreting and comparing data from these models can be challenging.

Jie Lu
Nicola Dalbeth
Wen-Hua Wei
Reviews22 May 2019
Nature Reviews Rheumatology

Volume: 15, P: 413-426
Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment

Guan Zheng
Zhongyu Xie
Huiyong Shen
ResearchOpen Access25 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-11
The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li
Zhongyu Xie
Huiyong Shen
ResearchOpen Access10 May 2018
Cell Death & Disease

Volume: 9, P: 1-13
Disulfidptosis-related genes serve as potential prognostic biomarkers and indicate tumor microenvironment characteristics and immunotherapy response in prostate cancer

Rongbin Zhou
Dingjin Lu
Fubo Wang
ResearchOpen Access19 Jun 2024
Scientific Reports

Volume: 14, P: 1-20
Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis

Guiwen Ye
Zhongyu Xie
Huiyong Shen
ResearchOpen Access17 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-13
An appearance quality classification method for Auricularia auricula based on deep learning

Yang Li
Jiajun Hu
Yongcheng Jiang
ResearchOpen Access05 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop

Mengjun Ma
Jiahao Zhuang
Huiyong Shen
ResearchOpen Access07 Nov 2023
Oncogene

Volume: 43, P: 47-60
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays

Mingyun Shen
Sheng Tian
Tingjun Hou
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-14

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