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Gel protects therapeutic proteins from deactivation — even in the post

The need to keep therapeutic proteins, such as insulin, constantly cold can limit access to life-saving medicines. An advanced gel offers a possible solution to this issue — and might solve problems beyond health-care logistics.

Yanxian Zhang
Danny Hung-Chieh Chou
News & Views17 Jul 2024
Nature

Volume: 631, P: 507-508
Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Xiaochun Xiong
John G. Menting
Danny Hung-Chieh Chou
Amendments and Corrections12 Jun 2020
Nature Structural & Molecular Biology

Volume: 27, P: 683
Routine whole spine magnetic resonance imaging for patients with anorectal malformations

Shao-Kang Su
Hung-Chieh Chen
Hou-Chuan Chen
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin 4 receptor.

Laetitia Coassolo
Niels B. Danneskiold-Samsøe
Katrin J. Svensson
Research05 Mar 2025
Nature

Volume: 641, P: 192-201
Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants

Yu-Hua Wen
Hwai-I. Yang
Po-Nien Tsao
ResearchOpen Access13 Sept 2019
Scientific Reports

Volume: 9, P: 1-8
Symmetric and asymmetric receptor conformation continuum induced by a new insulin

Identification of venom insulins with A-chain elongations inspired hybrid analogs with similar activity to human insulin. Cryo-EM structure analysis revealed the basis of the hybrid peptide activity.

Xiaochun Xiong
Alan Blakely
Danny Hung-Chieh Chou
Research14 Mar 2022
Nature Chemical Biology

Volume: 18, P: 511-519
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Insights from structural biology lead to the development of mini-Ins—a human des-octapeptide insulin analog that is monomeric and has receptor binding affinity and in vitro and in vivo activities comparable to those of human insulin.

Xiaochun Xiong
John G. Menting
Danny Hung-Chieh Chou
Research01 Jun 2020
Nature Structural & Molecular Biology

Volume: 27, P: 615-624
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Structural elucidation and biochemical analysis of a cone snail insulin venom that binds and activates the human insulin receptor may permit design of ultrafast-acting insulin analogs for diabetes therapy.

John G Menting
Joanna Gajewiak
Michael C Lawrence
Research12 Sept 2016
Nature Structural & Molecular Biology

Volume: 23, P: 916-920
Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease

Chou et al. develop a machine learning algorithm for the automated determination of cardiothoracic ratio (CTR). Both baseline CTRs and trajectories of serial CTR measurements are associated with end-stage renal disease and mortality in patients with chronic kidney disease.

Che-Yi Chou
Charles C. N. Wang
Chin-Chi Kuo
ResearchOpen Access07 Feb 2023
Communications Medicine

Volume: 3, P: 1-8
Unconventional insulins from predators and pathogens

Several venomous predators and pathogens use insulins to capture prey and to manipulate host physiology. This Review provides an overview of the discovery and potential biomedical application of these and other weaponized hormones found in nature.

Sophie Heiden Laugesen
Danny Hung-Chieh Chou
Helena Safavi-Hemami
Reviews27 Jun 2022
Nature Chemical Biology

Volume: 18, P: 688-697
211 G to A Variation of UDP-Glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice

Hung-Chieh Chou
Mei-Huei Chen
Po-Nien Tsao
Research01 Feb 2011
Pediatric Research

Volume: 69, P: 170-174

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Gel protects therapeutic proteins from deactivation — even in the post

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Routine whole spine magnetic resonance imaging for patients with anorectal malformations

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants

Symmetric and asymmetric receptor conformation continuum induced by a new insulin

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease

Unconventional insulins from predators and pathogens

211 G to A Variation of UDP-Glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice

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