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Showing 1–7 of 7 results
Advanced filters: Author: Hyerim Yi Clear advanced filters

  • Extrachromosomal DNA (ecDNA) drives oncogene amplification, tumour evolution and therapy resistance across cancers. This Review summarizes advances in ecDNA biology, highlights emerging therapeutic vulnerabilities and outlines strategies to improve ecDNA detection and translate ecDNA-targeted approaches from bench to bedside.

    • Ivy Tsz-Lo Wong
    • Hyerim Yi
    • Paul S. Mischel
    Reviews
    Nature Reviews Drug Discovery
    P: 1-16

  • Understanding the charge trapping mechanism in organic semiconductors is crucial to design molecules for high-performance organic photodetectors. Labanti et al. systematically investigate the impact of donor molecular structure on the energetic disorder that affects both shallow and deep trap formation.

    • Chiara Labanti
    • Jiaying Wu
    • Ji-Seon Kim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • A mRNA-interactome capture approach in embryonic stem cells (ESCs) has led to the identification of 283 novel RNA-binding protein (RBP) candidates, of which 68 are preferentially expressed in ESCs. Validation of two known E3 ubiquitin ligases as RBPs reveals an intriguing potential link between RNA biology and protein-modification pathways.

    • S Chul Kwon
    • Hyerim Yi
    • V Narry Kim
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1122-1130

  • The figure depicts a new type of transparent electrode recording array made of vertically aligned zinc oxide nanotubes grown on graphene (top middle). The nanotubes are formed by sharp nanowalls to penetrate the cell (top left) while transparent graphene layers allow imaging the neurons using with conventional microscopy (top right). As a result, simultaneous recording of electrical signals was obtained from multiple neurons at single-cell resolution. Moreover, the signals had distinguishable waveforms that implicated extracellular- and intracellular-like electrophysiological voltage changes (bottom).

    • Jamin Lee
    • Keundong Lee
    • Gyu-Chul Yi
    ResearchOpen Access
    NPG Asia Materials
    Volume: 16, P: 1-9