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Showing 1–19 of 19 results
Advanced filters: Author: Ian P. Wicks Clear advanced filters

  • This Perspective argues that dermal interstitial fluid cannot be generally considered a diagnostically useful proxy for blood, yet that it can offer advantageous utility for the monitoring of therapeutic drugs and of the status of the immune system.

    • Mark Friedel
    • Ian A. P. Thompson
    • Jason Heikenfeld
    Reviews
    Nature Biomedical Engineering
    Volume: 7, P: 1541-1555

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • G-CSF and GM-CSF are well-known regulators of hematopoiesis, but these cytokines also have proinflammatory activity and are expressed in the joints of patients with rheumatoid arthritis. Antagonism of G-CSF or GM-CSF might represent a novel, safe and effective way of treating this disease.

    • Ann L. Cornish
    • Ian K. Campbell
    • Ian P. Wicks
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 554-559

  • Although nectar is known to be important, for example in plant–insect interactions, little has been known about the mechanism of its secretion; sucrose phosphate synthases are now reported to be essential for the synthesis of the sucrose component of nectar and the transporter protein SWEET9 is shown to mediate sucrose export into the extracellular space of the nectary.

    • I Winnie Lin
    • Davide Sosso
    • Wolf B. Frommer
    Research
    Nature
    Volume: 508, P: 546-549

  • Polymyositis (PM) is a chronic inflammatory myopathy characterized by progressive muscle weakness. Here the authors showed that muscle fibers in PM undergo necroptosis and aggravate inflammation via releasing pro-inflammatory molecules such as HMGB1.

    • Mari Kamiya
    • Fumitaka Mizoguchi
    • Shinsuke Yasuda
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • MLKL is regarded as an executor of the necroptotic inflammatory cell death pathway. Here authors show, by introducing a mutation into mouse MLKL representing a frequently occurring human single nucleotide polymorphism, that MLKL mutations could critically alter the inflammatory response and the clearance of Salmonella from organs upon infection.

    • Sarah E. Garnish
    • Katherine R. Martin
    • Joanne M. Hildebrand
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • APLAID is a rare autoinflammatory disorder driven by mutations in PLCG2. Here the authors provide a new mouse model using the human APLAID p.Ser707Tyr mutation. The mouse recapitulates clinical features of APLAID that can be prevented by anti-G-CSF. Individuals with APLAID were also shown to have high circulating levels of G-CSF suggesting this might be a suitable target for the clinic.

    • Elisabeth Mulazzani
    • Klara Kong
    • Seth L. Masters
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 814-826

  • Group 2 innate lymphoid cells (ILC2s) are generally considered to have pro-tumor functions. However, Belz and colleagues demonstrate that ILC2s have anti-melanoma effects due to their high production of the inflammatory cytokine granulocyte-macrophage colony-stimulating factor in the tumor microenvironment.

    • Nicolas Jacquelot
    • Cyril Seillet
    • Gabrielle T. Belz
    Research
    Nature Immunology
    Volume: 22, P: 851-864

  • RIPK3 can cause necroptotic cell death via MLKL phosphorylation, and activate NLRP3 inflammasome. Here the authors show that MLKL is dispensable for NLRP3 activation by RIPK3, and highlight how different IAP proteins limit RIPK3 induced apoptosis, necroptosis and IL-1 secretion.

    • Kate E. Lawlor
    • Nufail Khan
    • James E. Vince
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-19

  • Neutrophils are powerful mediators of tissue inflammation, and the balance between neutrophil survival and clearance is crucial to the resolution of inflammation. The cytokine granulocyte colony-stimulating factor is an important regulator of neutrophil production and survival. This Review discusses the roles of neutrophils and granulocyte colony-stimulating factor in chronic inflammatory diseases.

    • Jo L Eyles
    • Andrew W Roberts
    • Ian P Wicks
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 2, P: 500-510

  • Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine with a wide range of biological effects that span innate and adaptive immunity processes. As our knowledge of the biology of GM-CSF improves, its potential as a therapeutic target in rheumatic diseases is being acknowledged, and the first early phase clinical trials of GM-CSF inhibition in patients with inflammatory disorders have produced encouraging results.

    • Ian P. Wicks
    • Andrew W. Roberts
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 37-48

  • Various types of programmed cell death, including necroptosis, pyroptosis, NETosis and apoptosis, contribute to acute and chronic inflammation, and dysregulation of these pathways is implicated in rheumatic diseases. Understanding the mechanisms and overlap between cell death pathways might lead to new therapies.

    • Holly Anderton
    • Ian P. Wicks
    • John Silke
    Reviews
    Nature Reviews Rheumatology
    Volume: 16, P: 496-513