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Advanced filters: Author: Ifeanyi K. Nmecha Clear advanced filters

miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1

miR-299a-5p is elevated in diabetic kidneys and in mesangial cells, promoting extracellular matrix buildup by reducing follistatin and cripto-1. This enhances activin A and TGFβ1 signaling. Its inhibition lessens fibrosis in diabetic kidneys.

Ifeanyi K. Nmecha
Bo Gao
Joan C. Krepinsky
ResearchOpen Access11 Dec 2025
Communications Biology

Volume: 9, P: 1-13
Both sexes develop DKD in the CD1 uninephrectomized streptozotocin mouse model

Jackie Trink
Ifeanyi Kennedy Nmecha
Joan C. Krepinsky
ResearchOpen Access03 Oct 2023
Scientific Reports

Volume: 13, P: 1-10

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miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1

Both sexes develop DKD in the CD1 uninephrectomized streptozotocin mouse model

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