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Secreted luciferases as a minimally invasive 3R-compliant tool for accurate monitoring of tumor burden

This protocol details in vitro and in vivo approaches for labeling tumor cells with secreted luciferases to enable precise, longitudinal monitoring of tumor growth in mice, through the analysis of small blood samples.

Nastasja Merle
Imke Bullwinkel
Thorsten Stiewe
Protocols03 Feb 2026
Nature Protocols

P: 1-34
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

A large-scale CRISPR-mediated deep mutational scanning approach is used to interrogate the function of mutations in the endogenous locus of TP53 mapping to the DNA-binding domain.

Julianne S. Funk
Maria Klimovich
Thorsten Stiewe
ResearchOpen Access07 Jan 2025
Nature Genetics

Volume: 57, P: 140-153

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Secreted luciferases as a minimally invasive 3R-compliant tool for accurate monitoring of tumor burden

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

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