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Showing 1–14 of 14 results

Advanced filters: Author: Iqbal Mahmud Clear advanced filters

High-throughput multi-organ proteomics workflow for drug efficacy and toxicity analysis

Mass spectrometry (MS)-based proteomics is increasingly central to systems biology. Here, the authors present a high-throughput, multi-organ workflow that profiles 11,472 proteins in 507 mouse samples, enabling rapid, system-level evaluation of drug efficacy and toxicity.

Yun Xiong
Lin Tan
Philip L. Lorenzi
ResearchOpen Access09 Feb 2026
Nature Communications

Volume: 17, P: 1-17
An efficient transformer architecture with depthwise separable convolutions for high-accuracy underwater acoustic target recognition

Nahid-Al Mahmud
Tao Zhang
Oleksandr Rubanenko
ResearchOpen Access17 Dec 2025
Scientific Reports

Volume: 16, P: 1-21
Immature Acta2^R179C/+ smooth muscle cells cause moyamoya-like cerebrovascular lesions in mice prevented by boosting OXPHOS

ACTA2 p.R179 variants cause pediatric strokes due to moyamoya disease (MMD)-like occlusions. Here, the authors show that Acta2^R179C/+ smooth muscle cells are immature, causing MMD-like lesions that are reversed by altering cellular metabolism.

Anita Kaw
Suravi Majumder
Dianna M. Milewicz
ResearchOpen Access02 Jul 2025
Nature Communications

Volume: 16, P: 1-20
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors

Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

Feiyu Chen
Haoyan Li
Di Zhao
Research13 May 2025
Nature Cancer

Volume: 6, P: 854-873
Ion suppression correction and normalization for non-targeted metabolomics

Metabolomics data quality is limited by ion suppression effects. Here, the authors present an IROA-based workflow that corrects these issues across diverse analytical conditions and reveals previously unknown metabolic changes in cancer therapy.

Iqbal Mahmud
Bo Wei
Philip L. Lorenzi
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

How cell cycling coordinates with cell survival and death remains unclear. Here, the authors reveal a suppressive effect of cell cycle arrest on ferroptosis and propose a ferroptosis-inducing approach to treat slow-cycling, therapy-resistant cancers.

Hyemin Lee
Amber Horbath
Boyi Gan
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis

Genetic and pharmacological inhibition of the overproduction of oxalate in the liver alleviates metabolic dysfunction-associated steatohepatitis in male mice.

Sandeep Das
Alexandra C. Finney
Oren Rom
ResearchOpen Access27 Sept 2024
Nature Metabolism

Volume: 6, P: 1939-1962
DAXX drives de novo lipogenesis and contributes to tumorigenesis

Cancer cells have altered lipid metabolism. Here the authors show that DAXX promotes lipogenesis and tumorigenesis through interaction with SREBP1/2.

Iqbal Mahmud
Guimei Tian
Daiqing Liao
ResearchOpen Access12 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Advertising, gender, and consumer culture in Bangladesh

Iqbal Ahmed Chowdhury
ResearchOpen Access10 Apr 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-11
Application of water based drilling clay-nanoparticles in heat transfer of fractional Maxwell fluid over an infinite flat surface

Muhammad Imran Asjad
Rizwan Ali
Yu-Ming Chu
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma

Chandrani Chattopadhyay
Janos Roszik
Elizabeth A. Grimm
ResearchOpen Access11 Oct 2024
British Journal of Cancer

Volume: 131, P: 1846-1857
Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment

Mokryun L. Baek
Junegoo Lee
Gloria V. Echeverria
Research22 Feb 2023
Oncogene

Volume: 42, P: 1117-1131
Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

Bongyong Lee
Iqbal Mahmud
Ranjan J. Perera
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-17
βArrestin2 Mediates Renal Cell Carcinoma Tumor Growth

Jude Masannat
Hamsa Thayele Purayil
Yehia Daaka
ResearchOpen Access20 Mar 2018
Scientific Reports

Volume: 8, P: 1-10