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Showing 1–2 of 2 results
Advanced filters: Author: Irene Boniardi Clear advanced filters

  • Sortilin mediates thyroglobulin endocytosis within the thyroid. Using structural biology, the authors reveal that sortilin acts as structural sensor of monomeric thyroglobulin, independently of its iodination and hormone content, via binding of a flexible C-terminal peptide.

    • Irene Boniardi
    • Giorgia Tanzi
    • Francesca Coscia
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Structural biology approaches are used to show how thyroxine is transported by monocarboxylate transporters (MCT)8 and 10, and MCT8 inhibition by silychristin. These findings shed light on how a MCT8 patient-derived mutation alters its function.

    • Matteo Tassinari
    • Giorgia Tanzi
    • Francesca Coscia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11