Nature Search

The aging of hematopoietic stem cells

Sean J. Morrison
Antoni M. Wandycz
Irving L. Weissman
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 1011-1016
Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation

Pamela J. Fink
W. Michael Gallatin
Irving L. Weissman
Research17 Jan 1985
Nature

Volume: 313, P: 233-235
A cell-surface molecule involved in organ-specific homing of lymphocytes

W. Michael Gallatin
Irving L. Weissman
Eugene C. Butcher
Research01 Jul 1983
Nature

Volume: 304, P: 30-34
Bone marrow cells give rise to distinct cell clones within the thymus

Sophie Ezine
Irving L. Weissman
Robert V. Rouse
Research14 Jun 1984
Nature

Volume: 309, P: 629-631
Stem cells

IRVING WEISSMAN
GERALD SPANGRUDE
NOBUKO UCHIDA
Research05 Sept 1991
Nature

Volume: 353, P: 26
Murine leukaemogenesis: monoclonal antibodies to T-cell determinants arrest T-lymphoma cell proliferation

Michael S. McGrath
Eric Pillemer
Irving L. Weissman
Research22 May 1980
Nature

Volume: 285, P: 259-261
Lyt markers on thymus cell migrants

ROLAND SCOLLAY
MOSZE KOCHEN
IRVING WEISSMAN
Research02 Nov 1978
Nature

Volume: 276, P: 79-80
B220: a B cell-specific member of the T200 glycoprotein family

Robert L. Coffman
Irving L. Weissman
Research19 Feb 1981
Nature

Volume: 289, P: 681-683
V–J joining of immunoglobulin κ genes only occurs on one homologous chromosome

Rolf Joho
Irving L. Weissman
Research13 Mar 1980
Nature

Volume: 284, P: 179-181
Mouse T-cell surface glycoprotein recognised by heterologous anti-thymocyte sera and its relationship to Thy-1 antigen

IAN S. TROWBRIDGE
IRVING L. WEISSMAN
MICHAEL J. BEVAN
Research21 Aug 1975
Nature

Volume: 256, P: 652-654
Evidence of continuous evolutionary change in structures mediating adherence of lymphocytes to specialised venules

EUGENE BUTCHER
ROLAND SCOLLAY
IRVING WEISSMAN
Research01 Aug 1979
Nature

Volume: 280, P: 496-498
The murine T-cell receptor uses a limited repertoire of expressed V_β gene segments

Richard K. Barth
Byung S. Kim
Leroy Hood
Research01 Aug 1985
Nature

Volume: 316, P: 517-523
Reply to “More or less hematopoietic stem cells”

Sean J. Morrison
Irving L. Weissman
Correspondence01 Dec 1996
Nature Medicine

Volume: 2, P: 1282-1283
Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics

Simultaneous profiling of adenylated and non-adenylated RNAs reveals regulatory programs across diverse cell types.

Alina Isakova
Daniel Dan Liu
Stephen R. Quake
ResearchOpen Access31 Mar 2026
Nature Biotechnology

P: 1-12
mRNA medicine for cardiovascular disease

Zhou et al. review recent technological advances in mRNA-based biotechnologies for cardiovascular disease, examining preclinical applications, clinical trial outcomes, and the key challenges and future directions of these approaches.

Zhuoming Zhou
Wei Chen
Wei Tao
Reviews14 Apr 2026
Nature Cardiovascular Research

P: 1-17
An immunoglobulin heavy-chain gene is formed by at least two recombinational events

Mark M. Davis
Kathryn Calame
Leroy Hood
Research21 Feb 1980
Nature

Volume: 283, P: 733-739
Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens

Engineered mucus-tethering bispecific nanobodies neutralize and entrap viruses to enhance mucosal immunity, preventing influenza infection and limiting SARS-CoV-2 transmission.

Liming Zhao
Kyle L. O’Donnell
Charles K. F. Chan
Research21 Jan 2026
Nature Nanotechnology

Volume: 21, P: 419-429
Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids

Hannah Alexander
David A. Johnson
Richard A. Lerner
Research15 Dec 1983
Nature

Volume: 306, P: 697-699
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

Antibody-mediated depletion of myeloid-biased haematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system.

Jason B. Ross
Lara M. Myers
Irving L. Weissman
Research27 Mar 2024
Nature

Volume: 628, P: 162-170
In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis

Juan M. Arriaga
Kacey Ronaldson-Bouchard
Cory Abate-Shen
Research07 Mar 2024
Oncogene

Volume: 43, P: 1303-1315
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Eric Lagasse
Heather Connors
Markus Grompe
Research01 Nov 2000
Nature Medicine

Volume: 6, P: 1229-1234
Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature

Rinkevich, Weissman and colleagues show that mesothelin-expressing cells from the mesothelium, an epithelial monolayer covering vertebrate cavities and internal organs, generate the fibroblasts and smooth muscle cells (FSMCs) essential for the development of internal organs. Using a genetic lineage tracing approach, they find that these cells participate in generating FSMCs and vasculature, with minimal contributions from neural crest or circulating cells.

Yuval Rinkevich
Taisuke Mori
Irving L. Weissman
Research11 Nov 2012
Nature Cell Biology

Volume: 14, P: 1251-1260
Programmed cell removal: a new obstacle in the road to developing cancer

Recent evidence indicates that successful cancer clones must have overcome programmed cell removal. In this Opinion article, the authors explore the role of programmed cell removal in both normal and neoplastic cells.

Mark P. Chao
Ravindra Majeti
Irving L. Weissman
Reviews08 Dec 2011
Nature Reviews Cancer

Volume: 12, P: 58-67
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions

Miriam Merad
Markus G. Manz
Edgar G. Engleman
Amendments and Corrections04 Apr 2025
Nature Immunology

Volume: 26, P: 805
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.

James Y. Chen
Masanori Miyanishi
Irving L. Weissman
Research10 Feb 2016
Nature

Volume: 530, P: 223-227
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Richard A. F. Dixon
Brian K. Kobilka
Catherine D. Strader
Research01 May 1986
Nature

Volume: 321, P: 75-79
Discriminating cellular heterogeneity using microwell-based RNA cytometry

Haematopoietic stem cell populations contain subgroups with distinct gene expression signatures and functional properties. Here, the authors present a method to uncover such subpopulations, based on flow cytometry to sort single cells into a microwell array followed by RNA expression measurements and statistical analyses.

Ivan K. Dimov
Rong Lu
Luke P. Lee
Research25 Mar 2014
Nature Communications

Volume: 5, P: 1-12
Erratum: Langerhans cells renew in the skin throughout life under steady-state conditions

Miriam Merad
Markus G. Manz
Edgar G. Engleman
Amendments and Corrections01 Jan 2003
Nature Immunology

Volume: 4, P: 92
Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Irina M. Conboy
Michael J. Conboy
Thomas A. Rando
Research17 Feb 2005
Nature

Volume: 433, P: 760-764
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Host cells display ‘don’t eat me’ signals to protect themselves from phagocytosis. Maute and colleagues identify a novel ‘don’t eat me’ system based on recognition of MHC class I by the phagocyte-expressed inhibitory molecule LILRB1.

Amira A. Barkal
Kipp Weiskopf
Roy L. Maute
Research27 Nov 2017
Nature Immunology

Volume: 19, P: 76-84
Erratum: Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

Miriam Merad
Petra Hoffmann
Edgar G Engleman
Amendments and Corrections01 Jun 2004
Nature Medicine

Volume: 10, P: 649
A molecular cell atlas of mouse lemur, an emerging model primate

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Antoine de Morree
Iwijn De Vlaminck
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 173-184
Sleep disruption impairs haematopoietic stem cell transplantation in mice

How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.

Asya Rolls
Wendy W. Pang
Luis de Lecea
Research14 Oct 2015
Nature Communications

Volume: 6, P: 1-9
Programmed cell removal by calreticulin in tissue homeostasis and cancer

Macrophage-mediated programmed cell removal (PrCR) allows clearance of living cells. Here the authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on cancer cells, determining in both cases clearance by PrCR.

Mingye Feng
Kristopher D. Marjon
Irving L. Weissman
ResearchOpen Access10 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

Nishiga and colleagues show therapeutic efficacy for a combination of radiotherapy and CD47 blockade, which also elicits an abscopal effect mediated by macrophages migrating into non-irradiated tumor sites and phagocytosing cancer cells.

Yoko Nishiga
Alexandros P. Drainas
Julien Sage
ResearchOpen Access21 Nov 2022
Nature Cancer

Volume: 3, P: 1351-1366
Erratum: Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

Alexander D. Boiko
Olga V. Razorenova
Irving L. Weissman
Amendments and Corrections16 Feb 2011
Nature

Volume: 470, P: 424
Complex mammalian-like haematopoietic system found in a colonial chordate

The identification of a complex haematopoietic system in a colonial tunicate sheds light on the evolution of the mammalian blood system.

Benyamin Rosental
Mark Kowarsky
Ayelet Voskoboynik
Research05 Dec 2018
Nature

Volume: 564, P: 425-429
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

Leora B. Balsam
Amy J. Wagers
Robert C. Robbins
Research21 Mar 2004
Nature

Volume: 428, P: 668-673
Engineered CD47 protects T cells for enhanced antitumour immunity

Combination of TCR or CAR T cells expressing the engineered CD47 variant 47_E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.

Sean A. Yamada-Hunter
Johanna Theruvath
Crystal L. Mackall
ResearchOpen Access15 May 2024
Nature

Volume: 630, P: 457-465
CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation

Engineering macrophages to express chimeric antigen receptors (CARs) for targeted tumor cell phagocytosis has shown encouraging results. Here the authors engineer macrophages with enhanced synthetic phagocytosis receptors which incorporate a FcRɣ-driven phagocytosis CAR and an auto-secreted CD47 blocker, showing improved anti-tumor efficacy

Siqi Chen
Yingyu Wang
Mingye Feng
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Wnt proteins are lipid-modified and can act as stem cell growth factors

Karl Willert
Jeffrey D. Brown
Roel Nusse
Research27 Apr 2003
Nature

Volume: 423, P: 448-452
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Identifying KRAS-specific vulnerabilities helps to target KRAS-driven cancer. Here the authors perform RNA interference screens in 3D cultures of primary tumour cells with KRAS activation and p53 loss and identify UHRF1 as a vulnerability of KRAS-mutant lung cancers

Kaja Kostyrko
Marta Román
E. Alejandro Sweet-Cordero
ResearchOpen Access05 Jul 2023
Nature Communications

Volume: 14, P: 1-18
Endochondral ossification is required for haematopoietic stem-cell niche formation

This paper describes an in vivo assay of haematopoietic stem cell (HSC) niche formation. A population of progenitor cells is sorted from fetal bones, and when transplanted under the adult mouse kidney capsule, the cells recruit host-derived blood vessels, produce donor-derived ectopic bones, and generate a marrow cavity populated by host-derived long-term reconstituting haematopoeitic stem cells.

Charles K. F. Chan
Ching-Cheng Chen
Irving L. Weissman
Research10 Dec 2008
Nature

Volume: 457, P: 490-494
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis

Jarr and colleagues show that statins augment efferocytosis by inhibiting the nuclear translocation of NF-κB1 p50 and suppressing the expression of the key ‘don’t-eat-me’ molecule CD47, which in part explains the pleiotropic effects of statins and provides a basis for future translational efforts.

Kai-Uwe Jarr
Jianqin Ye
Nicholas J. Leeper
Research07 Mar 2022
Nature Cardiovascular Research

Volume: 1, P: 253-262
SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease

The genetic basis of susceptibility to Lyme disease is largely unknown. Here, the authors discover a risk locus in the gene encoding the protein Secretoglobin family 1D member 2, which is expressed in skin and affects infection by the bacteria that causes Lyme disease in vitro and in vivo.

Satu Strausz
Erik Abner
Hanna M. Ollila
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-11
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

Motonari Kondo
David C. Scherer
Irving L. Weissman
Research21 Sept 2000
Nature

Volume: 407, P: 383-386
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

Antibodies against Plasmodium falciparum glutamic-acid-rich protein (PfGARP), an antigen expressed on the surface of infected red blood cells, kill P. falciparum parasites by inducing programmed cell death and reduce the risk of severe malaria.

Dipak K. Raj
Alok Das Mohapatra
Jonathan D. Kurtis
Research22 Apr 2020
Nature

Volume: 582, P: 104-108
Mouse lemur cell atlas informs primate genes, physiology and disease

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Camille Ezran
Shixuan Liu
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 185-196
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Koichi Akashi
David Traver
Irving L. Weissman
Research09 Mar 2000
Nature

Volume: 404, P: 193-197
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

DNA damage does not significantly impact in the establishment, maintenance or expansion of long-term reconstituting haematopoietic stem cells (LT-HSC), it is instead a physiological mechanism of stem cell ageing that may underlie the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury.

Derrick J. Rossi
David Bryder
Irving L. Weissman
Research07 Jun 2007
Nature

Volume: 447, P: 725-729

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