Expanding the complexity of genetically encoded peptides is a long-standing challenge at the intersection of chemistry and biology. Now it has been shown that linear peptides with a reactive N-terminal β- or γ-keto amide can be synthesized ribosomally and elaborated to generate atropisomeric and/or macrocyclic peptides with embedded pharmacophores.
- Isaac J. Knudson
- Taylor L. Dover
- Scott J. Miller
