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Neoadjuvant immune checkpoint blockade before chemoradiation for cervical squamous carcinoma (GINECO window-of-opportunity COLIBRI study): a phase II trial

Pre-treatment dual immune checkpoint blockade in cervical cancer remains understudied. In this trial, the authors show that neoadjuvant immune checkpoint blockade enhances immune activation and correlates with improved response to subsequent chemoradiation in patients with cervical carcinoma.

Isabelle Ray-Coquard
Marie-Christine Kaminsky-Forrett
Sarah Bétrian
ResearchOpen Access05 Jan 2026
Nature Communications

Volume: 17, P: 1-13
Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horses

The present study shows that maternal presence beyond early life remains crucial for brain, behavioural and physiological development in young horses, highlighting the importance of the mother–offspring relationship during a childhood-like stage.

Mathilde Valenchon
Fabrice Reigner
David André Barrière
ResearchOpen Access13 Jan 2026
Nature Communications

Volume: 17, P: 1-18
ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing

A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts.

Paula Clemente
Javier Calvo-Garrido
Anna Wredenberg
ResearchOpen Access30 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a cohort of post-treatment controllers.

Luis M. Molinos-Albert
Valérie Lorin
Laetitia Laine
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-17
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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Neoadjuvant immune checkpoint blockade before chemoradiation for cervical squamous carcinoma (GINECO window-of-opportunity COLIBRI study): a phase II trial

Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horses

ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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