Chromosomal translocations involving the gene encoding MOZ, a transcriptional regulator, can result in the production of fusion proteins that promote acute myeloid leukemia. In a mouse model of acute myeloid leukemia induced by a MOZ-containing fusion protein, Yukiko Aikawa et al. now identify a potential new therapeutic target, the cytokine receptor CSF1R, which is present on leukemia stem cells and is needed for leukemia induction and progression.
- Yukiko Aikawa
- Takuo Katsumoto
- Issay Kitabayashi
