Neutrophil extracellular traps (NETs) play multifaceted roles in numerous neutrophil-mediated diseases. The authors show that inhibiting cathepsin C ameliorates ANCA-associated vasculitis, a NET-related disorder, by reducing neutrophil serine protease activity and NET formation in a rat model.
- Yuka Nishibata
- Suishin Arai
- Akihiro Ishizu
