Nature Search

A cryptic third active site in cyanophycin synthetase creates primers for polymerization

Cyanophycin synthetase CphA1 polymerizes Asp and Arg into the nitrogen reserve polymer cyanophycin using two active sites. Sharon et al. show CphA1 has a cryptic 3rd active site that cleaves cyanophycin into primers for self-sufficient biosynthesis.

Itai Sharon
Sharon Pinus
T. Martin Schmeing
ResearchOpen Access07 Jul 2022
Nature Communications

Volume: 13, P: 1-10
Evidence for persistent and shared bacterial strains against a background of largely unique gut colonization in hospitalized premature infants

Tali Raveh-Sadka
Brian Firek
Jillian F Banfield
Research03 Jun 2016
The ISME Journal

Volume: 10, P: 2817-2830
Photosystem I gene cassettes are present in marine virus genomes

Cyanobacteria are important contributors to photosynthetic productivity in the open oceans. Functional photosystem II components are known to be encoded in cyanophage genomes and are suggested to provide a fitness advantage to the virus by boosting host performance. It is now shown that photosystem I components can also be detected in cyanophages.

Itai Sharon
Ariella Alperovitch
Oded Béjà
Research26 Aug 2009
Nature

Volume: 461, P: 258-262
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.

Yfat Yahalom-Ronen
Hadas Tamir
Tomer Israely
ResearchOpen Access16 Dec 2020
Nature Communications

Volume: 11, P: 1-13
Structures and function of the amino acid polymerase cyanophycin synthetase

Structures of three cyanophycin synthetases reveal how the constituent glutathione synthetase and muramyl ligase-like domains cooperate to make cyanophycin, a poly-aspartate chain with arginine residues attached to the sidechains by isopeptide bonds.

Itai Sharon
Asfarul S. Haque
T. Martin Schmeing
Research12 Aug 2021
Nature Chemical Biology

Volume: 17, P: 1101-1110
Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems

It is thought that CRISPR-Cas systems, which confer acquired immunity to phage and archaeal viruses, are widespread among bacteria and archaea. Here, Burstein et al.show that entire lineages of uncultivated microorganisms are essentially devoid of CRISPR-Cas systems.

David Burstein
Christine L. Sun
Jillian F. Banfield
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-8
A myovirus encoding both photosystem I and II proteins enhances cyclic electron flow in infected Prochlorococcus cells

Isolation of a cyanophage encoding photosystem I genes reveals that these are expressed during infection and inserted into host membranes, resulting in enhanced electron flow, and that phage carrying these genes are abundant in marine environments.

Svetlana Fridman
José Flores-Uribe
Oded Béjà
Research07 Aug 2017
Nature Microbiology

Volume: 2, P: 1350-1357
Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization

In this study, Omry Koren, Samuli Rautava and colleagues report a sex-specific association between neonatal antibiotic exposure and weight and height gain during the first six years of life and showing that boys but not girls exposed to neonatal antibiotics exhibit impaired weight and height development.

Atara Uzan-Yulzari
Olli Turta
Omry Koren
ResearchOpen Access26 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

Nonribosomal peptide synthetases work with additional enzymes to synthesise secondary metabolites and therapeutics. Here, the authors explore bacillamide D synthesis and show the oxidase action is done while the intermediate is attached to the synthetase and replicate this with an oxidase bound synthetase for bioengineering applications.

Camille Marie Fortinez
Kristjan Bloudoff
T. Martin Schmeing
ResearchOpen Access27 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria

Most cyanobacteria are oxygenic photoautotrophs, and fermenters under dark anoxic conditions. Here, the authors analyse genomic sequences of related uncultivated bacteria, inferring their metabolic potential, and supporting that their common ancestor was an anaerobe capable of fermentation and H₂ metabolism.

Paula B. Matheus Carnevali
Frederik Schulz
Jillian F. Banfield
ResearchOpen Access28 Jan 2019
Nature Communications

Volume: 10, P: 1-15
Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system

Microorganisms from the terrestrial subsurface are understudied. Here, Anantharamanet al. analyse aquifer sediments and groundwater by genome-resolved metagenomics and reconstruct 2,540 genomes representing the majority of known bacterial phyla as well as 47 new phylum-level lineages.

Karthik Anantharaman
Christopher T. Brown
Jillian F. Banfield
ResearchOpen Access24 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Genomic island variability facilitates Prochlorococcus–virus coexistence

Sarit Avrani
Omri Wurtzel
Debbie Lindell
Research29 Jun 2011
Nature

Volume: 474, P: 604-608
Comparative metagenomics of microbial traits within oceanic viral communities

Itai Sharon
Natalia Battchikova
Oded Béjà
Research10 Feb 2011
The ISME Journal

Volume: 5, P: 1178-1190
Cyanophage-encoded lipid desaturases: oceanic distribution, diversity and function

Sheila Roitman
Ellen Hornung
Oded Béjà
ResearchOpen Access13 Oct 2017
The ISME Journal

Volume: 12, P: 343-355
Author Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria

Paula B. Matheus Carnevali
Frederik Schulz
Jillian F. Banfield
Amendments and CorrectionsOpen Access26 Mar 2019
Nature Communications

Volume: 10, P: 1
Tumor cell-intrinsic PD-1 regulates chemotherapy resistance in colorectal cancer cells by activating downstream MAPK signaling

Ho Kit Mok
Sophie Sneddon
Isabella T. Tai
ResearchOpen Access19 Nov 2025
BJC Reports

Volume: 3, P: 1-12
Cultivation of bovine lipid chunks on Aloe vera scaffolds

Gilad Gome
Benyamin Chak
Sharon Schlesinger
ResearchOpen Access25 Feb 2025
npj Science of Food

Volume: 9, P: 1-9
A distinct abundant group of microbial rhodopsins discovered using functional metagenomics

An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

Alina Pushkarev
Keiichi Inoue
Oded Béjà
Research20 Jun 2018
Nature

Volume: 558, P: 595-599
Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection

Itai M. Magodoro
Carlos E. Guerrero-Chalela
Ntobeko A. B. Ntusi
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Comparative community genomics in the Dead Sea: an increasingly extreme environment

Idan Bodaker
Itai Sharon
Oded Béjà
Research24 Dec 2009
The ISME Journal

Volume: 4, P: 399-407
Microbial community genomics in eastern Mediterranean Sea surface waters

Roi Feingersch
Marcelino T Suzuki
Oded Béjà
Research20 Aug 2009
The ISME Journal

Volume: 4, P: 78-87
Unusual biology across a group comprising more than 15% of domain Bacteria

More than 15% of the bacterial domain consists of a radiation of phyla about which very little is known; here, metagenomics is used to reconstruct 8 complete and 789 draft genomes from more than 35 of these phyla, revealing a shared evolutionary history, metabolic limitations, and unusual ribosome compositions.

Christopher T. Brown
Laura A. Hug
Jillian F. Banfield
Research15 Jun 2015
Nature

Volume: 523, P: 208-211
Widespread distribution of proteorhodopsins in freshwater and brackish ecosystems

Nof Atamna-Ismaeel
Gazalah Sabehi
Oded Beja
Research27 Mar 2008
The ISME Journal

Volume: 2, P: 656-662
Erratum: Widespread distribution of proteorhodopsins in freshwater and brackish ecosystems

Nof Atamna-Ismaeel
Gazalah Sabehi
Oded Beja
Amendments and Corrections16 Feb 2010
The ISME Journal

Volume: 4, P: 462
Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation

Itai Sharon
T. Martin Schmeing
ResearchOpen Access23 May 2023
Scientific Reports

Volume: 13, P: 1-10
Metabolic interdependencies between phylogenetically novel fermenters and respiratory organisms in an unconfined aquifer

Kelly C Wrighton
Cindy J Castelle
Jillian F Banfield
Research13 Mar 2014
The ISME Journal

Volume: 8, P: 1452-1463
The chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70

Conrado C. Gonçalves
Itai Sharon
Jason C. Young
ResearchOpen Access24 Aug 2021
Scientific Reports

Volume: 11, P: 1-16
Viral photosynthetic reaction center genes and transcripts in the marine environment

Itai Sharon
Shani Tzahor
Oded Béjà
Research09 Aug 2007
The ISME Journal

Volume: 1, P: 492-501
Biostimulation induces syntrophic interactions that impact C, S and N cycling in a sediment microbial community

Kim M Handley
Nathan C VerBerkmoes
Jillian F Banfield
Research29 Nov 2012
The ISME Journal

Volume: 7, P: 800-816
RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria

Kelly C Wrighton
Cindy J Castelle
Jillian F Banfield
ResearchOpen Access03 May 2016
The ISME Journal

Volume: 10, P: 2702-2714

Search

A cryptic third active site in cyanophycin synthetase creates primers for polymerization

Evidence for persistent and shared bacterial strains against a background of largely unique gut colonization in hospitalized premature infants

Photosystem I gene cassettes are present in marine virus genomes

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Structures and function of the amino acid polymerase cyanophycin synthetase

Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems

A myovirus encoding both photosystem I and II proteins enhances cyclic electron flow in infected Prochlorococcus cells

Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization

Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria

Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system

Genomic island variability facilitates Prochlorococcus–virus coexistence

Comparative metagenomics of microbial traits within oceanic viral communities

Cyanophage-encoded lipid desaturases: oceanic distribution, diversity and function

Author Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria

Tumor cell-intrinsic PD-1 regulates chemotherapy resistance in colorectal cancer cells by activating downstream MAPK signaling

Cultivation of bovine lipid chunks on Aloe vera scaffolds

A distinct abundant group of microbial rhodopsins discovered using functional metagenomics

Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection

Comparative community genomics in the Dead Sea: an increasingly extreme environment

Microbial community genomics in eastern Mediterranean Sea surface waters

Unusual biology across a group comprising more than 15% of domain Bacteria

Widespread distribution of proteorhodopsins in freshwater and brackish ecosystems

Erratum: Widespread distribution of proteorhodopsins in freshwater and brackish ecosystems

Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation

Metabolic interdependencies between phylogenetically novel fermenters and respiratory organisms in an unconfined aquifer

The chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70

Viral photosynthetic reaction center genes and transcripts in the marine environment

Biostimulation induces syntrophic interactions that impact C, S and N cycling in a sediment microbial community

RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria

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