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Advanced filters: Author: Ivo Zemp Clear advanced filters

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis

Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D genome organization, gene expression and cell fate determination.

Renard Lewis
Virginia Sinigiani
Ulrike Kutay
ResearchOpen Access24 Feb 2026
Nature Cell Biology

Volume: 28, P: 536-552
Structural basis for the final steps of human 40S ribosome maturation

Studies of five cryo-electron microscopy structures reveal the composition and conformational progression in the final maturation events of human 40S ribosomal subunit assembly.

Michael Ameismeier
Ivo Zemp
Roland Beckmann
Research18 Nov 2020
Nature

Volume: 587, P: 683-687

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LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis

Structural basis for the final steps of human 40S ribosome maturation

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