Search

Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior.

Regarding the failure and flow of wet soil, a question that remains is how soil material composition influences rheology. Based on Soft Earth suspension flow experiments, the authors discover a continuous transition from frictional-to-cohesive rheology recreating all complex behaviors reported for natural soil slurries.

The ABC transporter MRP2/ABCC2 is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. Dysfunction leads to Dubin-Johnson syndrome. Here the authors provide structural and biochemical evidence on the modulation of MRP2 by intracellular kinases and inhibition by therapeutic drugs.

Cowden et al. use nationally representative data from 22 countries (N = 202,898) included in Wave 1 of the Global Flourishing Study to explore the distribution of suffering in each country and identify sociodemographic disparities in suffering. Findings show that suffering varies considerably across countries and some sociodemographic categories.

The 1.94 Å cryo-EM structure of the Lhcp trimer from a prasinophyte Ostreococcus tauri reveals all pigments, including a unique carotenoid aiding trimer stabilization. Comparison with LHCII links structural differences to enhanced blue light absorption.

While biodiversity levels have been studied in many different landscapes, villages have been relatively unexplored in comparison. This study examines biodiversity in Eastern European villages across landscape complexity and proximity to cities in the context of social and economic well-being.

Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and molecular dynamics simulations provide insights into the catalytic mechanism of Nsp15 and its conformational dynamics.

Statistical mapping techniques provide insights into the spread of two key arbovirus vectors in Europe and the United States, and predict the future distributions of both mosquitoes in response to accelerating urbanization, connectivity and climate change.

Interpreting genetic variation in the noncoding genome remains challenging, with functional effects difficult to predict. Here, the authors perform saturation mutagenesis combined with massively parallel reporter assays for 20 disease-associated regulatory elements, quantifying the effects of over 30,000 variants.

This study looks at all municipalities in the United States to identify smart cities and their links to SDGs. Through text-mining and manual verification, it identifies 397 smart cities with specific disparities between smart and non-smart cities in several SDGs.

CIBERSORTx, a suite of computational tools, enables inference of cell type abundance and cell-type-specific gene expression profiles from bulk RNA profiles.

Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that regulate its enzymatic activity.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Higher education in science should never be specifically for employment, but if it can retain its educative function, while taking some cognizance of the possible shape of the market for its products, the frustrations and disappointments suffered by so many individual science graduates during the past few years may be somewhat lessened in future.

Comparing experimental mass spectra to reference spectra can enable natural product identification, but these spectral libraries are often incomplete and not universally applicable. Here, the authors present SNAP-MS, a tool that allows assigning compound families without experimental or calculated reference spectra.

Predicting who will develop skin cancer is difficult. Here, the authors from 23andMe developed a polygenic risk score for skin cancer based on a questionnaire and genetic data from more than 210,000 individuals and suggest that the score could be used in early screening programmes.

The Inflation Reduction Act increases the competitiveness of US electric vehicle battery manufacturing and incentivizes supply chain diversification, but reducing vulnerabilities will depend on automaker choices in battery design and navigating regulations.

Cost, supply and logistics present challenges to COVID-19 vaccine rollout in low and middle income countries. Here, the authors model vaccination programmes in South Africa and demonstrate the importance of the pace of vaccine rollout, with even moderately efficacious vaccines likely to be cost-effective.

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domain as essential for virus replication.

Here, using cryo-EM, the authors reveal the mechanism by which RecA filamented on single-stranded DNA binds to and induces LexA cleavage, the key signal governing the bacterial DNA damage response pathway implicated in antibiotic resistance.

The risks to human well-being of floods in the United States have long been overlooked and underestimated, particularly for low-income and marginalized communities. In Los Angeles, flood risks are disproportionately high for historically disadvantaged populations and communities already facing social inequities.

l-cysteine is required for the growth of Lactobacillus iners, a vaginal microbiome species typically associated with adverse outcomes that lacks cysteine biosynthesis pathways and key uptake mechanisms present in other lactobacilli. Cystine uptake inhibitors can be used to suppress L. iners abundance in vitro in favour of L. crispatus, a species associated with favourable outcomes.

Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.

The exposure of populations to sea-level rise is a leading indicator assessing the impact of future climate change on coastal regions. The authors identify three spatial zones of flooding such as mean higher water, the 100 year floodplain and the low-elevation coastal zone and show population exposure can differ between those zones.

Lightning Pose is an efficient pose estimation approach that requires few labeled training data owing to its semi-supervised learning strategy and ensembling.

RNA modifications appear to play a role in determining RNA structure and function. Here, the authors develop a deep learning model that predicts the location of 12 RNA modifications using primary sequence, and show that several modifications are associated, which suggests dependencies between them.

In this study, the authors investigate the dissemination and evolution of vaccination-induced antibody lineages in macaques and show that members of neutralizing lineages acquire different breadths allowing recognition of both previously encountered and not encountered viral variants.

Phylogenetic trees are generated from sequencing reads without genome assembly or annotation.