Argonaute family members are key effectors of small RNA function. Predicted structural analogies to allosterically-regulated bacterial ligand-binding proteins, followed by biochemical analysis of the binding properties of Argonautes, now indicate functional allostery between two distinct binding sites that would promote a functional outcome when both a miRNA and capped mRNA are present.
- Sergej Djuranovic
- Michelle Kim Zinchenko
- Rachel Green
