The epigenetic factor Bmi1 regulates self-renewal of many adult stem cells, but its role in heart function is unknown. Here the authors show that Bmi1 prevents cardiac senescence by inhibiting the tumor suppressor protein p16INK4ain adult mice, protecting them from dilated cardiomyopathy and heart failure.
- I. Gonzalez-Valdes
- I. Hidalgo
- S. Gonzalez
