Three-dimensional nitrogen-rich bridged systems are of great importance in drug design. Now, a synthetic strategy enabling their preparation from readily available starting materials has been developed. This approach provides access to unstabilized C,N,N-cyclic azomethine imines, which are obtained as bench-stable dimers and undergo [3 + 2] cycloaddition reactions with various dipolarophiles.
- Yaseen A. Almehmadi
- Jack McGeehan
- Darren J. Dixon
