The mechanisms through which β-amyloid impairs human memory remain unclear. This study shows that regional-specific β-amyloid load in cognitively normal older adults impairs NREM slow wave oscillations, thereby compromising overnight hippocampus-dependent memory consolidation. NREM sleep disruption therefore represents a novel mechanistic pathway through which β-amyloid contributes to hippocampus-dependent memory dysfunction in later life.
- Bryce A Mander
- Shawn M Marks
- Matthew P Walker
