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Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8⁺ T cells

Kohlmeier and colleagues showed that the airway environment drove transcriptional and epigenetic changes that regulated the cytolytic functions of airway T_RM cells and promoted their apoptosis due to amino acid starvation and activation of the integrated stress response.

Sarah L. Hayward
Christopher D. Scharer
Jacob E. Kohlmeier
Research17 Jan 2020
Nature Immunology

Volume: 21, P: 309-320
Dural ectasia in the Marfan syndrome: MR and CT findings and criteria

Nicholas U Ahn
Paul D Sponseller
S James Zinreich
Research01 May 2000
Genetics in Medicine

Volume: 2, P: 173-179
An aberrant immune–epithelial progenitor niche drives viral lung sequelae

CD8⁺ T cell–macrophage interactions have a central role in impairing alveolar regeneration and driving fibrotic sequelae after acute viral pneumonia in a mouse model of long COVID.

Harish Narasimhan
In Su Cheon
Jie Sun
Research04 Sept 2024
Nature

Volume: 634, P: 961-969
Prevention of respiratory virus transmission by resident memory CD8⁺ T cells

Experiments in a mouse model of natural parainfluenza virus transmission show that tissue-resident memory T cells in the respiratory tract have important interferon-γ-dependent roles in protection against and limiting the transmission of viral disease.

Ida Uddbäck
Sarah E. Michalets
Jacob E. Kohlmeier
Research12 Dec 2023
Nature

Volume: 626, P: 392-400
GLP-1-directed NMDA receptor antagonism for obesity treatment

Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.

Jonas Petersen
Mette Q. Ludwig
Christoffer Clemmensen
ResearchOpen Access15 May 2024
Nature

Volume: 629, P: 1133-1141
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.

Benjamin G. Barwick
Christopher D. Scharer
Jeremy M. Boss
ResearchOpen Access15 May 2018
Nature Communications

Volume: 9, P: 1-14
Migration, maintenance and recall of memory T cells in peripheral tissues

Memory T cells in non-lymphoid tissues provide an important early line of defence against secondary pathogen infection. In this article, the mechanisms involved in the migration, maintenance and function of memory T cells at these peripheral sites are discussed.

David L. Woodland
Jacob E. Kohlmeier
Reviews01 Mar 2009
Nature Reviews Immunology

Volume: 9, P: 153-161
Long-term maintenance of lung resident memory T cells is mediated by persistent antigen

Ida Uddbäck
Emily K. Cartwright
Jan P. Christensen
Research09 Jun 2020
Mucosal Immunology

Volume: 14, P: 92-99
The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus

Nan Jia
Lauren Byrd-Leotis
Richard D. Cummings
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-14
Pulmonary monocytes interact with effector T cells in the lung tissue to drive T_RM differentiation following viral infection

Paul R. Dunbar
Emily K. Cartwright
Jacob E. Kohlmeier
Research13 Nov 2019
Mucosal Immunology

Volume: 13, P: 161-171
Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma

Sean R. McMaster
Alexander N. Wein
Jacob E. Kohlmeier
Research16 Feb 2018
Mucosal Immunology

Volume: 11, P: 1071-1078

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