Search

EGFR inhibitors are standard of care in patients with EGFR-mutant non-small cell lung cancer (NSCLC) but resistance often develops. Here the authors report that the evolution of EGFR inhibitor resistance in EGFR-mutant NSCLC results in a sensitivity to the compound, MCB-613, and investigate the underlying mechanism of action.

Physicists have shown that a quantum object can be at least as big as a cluster of 7,000 sodium atoms. Plus, the oldest-known cave art in the world and why girls are starting puberty earlier than ever.

Vagus nerve signalling causes damaging post-heart-attack inflammation. Plus, why birds decorate their nests with ‘tails’ and the health benefits of forest bathing.

A mitochondria-induced metabolic pathway helps cancer cells lay low in lymph nodes. Plus, why this year’s flu season is so bad and tips on how to overcome ‘the fear of the blank page’.

A new material can switch from matte to shiny and display a variety of other effects as required. Plus, humans were using poison arrows 60,000 years ago and the quest to authenticate a da Vinci drawing using DNA.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Jacob Smith interviews microbiologists from around the world for their insights about what’s next for the field. Despite numerous challenges, optimism and creativity are poised to usher in an exciting new era of microbiology.

An artificial-intelligence market crash could drive AI researchers back into academia, experts say. Plus, the ethics of brain implants that detect ‘preconscious’ thoughts and a gene-editing tool that could tackle multiple diseases.

Global emissions could already be declining, some climate scientists argue. Plus, a new malaria drug that could combat treatment-resistant parasites and a day in the life of a dairy-cow researcher.

‘No one epidemic’ ravaged Napoleon’s troops on their retreat from Moscow, researchers say. Plus, large language models are sycophants and the art restorer working to preserve the history of Pompeii.

AI model can translate scenes in your head into sentences. Plus, iguanas were wrongly accused of invading a Mexican island and the ‘shadow scholars’ paid to write for others.

A cold-activated protein protects the bowhead whale’s DNA from dangerous mutations. Plus, an elephant-inspired bioprinter and a new way to test the progress of artificial intelligence.

A group of neurons in mice stay active long after an initial pain response. Plus, how AI agents might change research and the winners of this year’s ‘genius grants’.

Can you spot the penguin in every game this year?

mRNA vaccines seem to ‘rev up’ the immune system to boost immunotherapy. Plus, a rare meteorite has been recovered from the Moon and the mysterious transition between wakefulness and sleep.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

How primatologist Jane Goodall changed what it means to be a scientist. Plus, a historic treaty to protect the world’s seas has been ratified and a parachute that’s intentionally full of holes.

The first major LLM to undergo peer-review, the rise of ‘griefbots’ and a model that can make disease predictions from a person’s health records are among the latest in AI news. Plus, the World Health Organization has downgraded the international emergency status of mpox.

Illnesses such as COVID-19 and flu can rouse sleeping cancer cells. Plus, a miniature neutrino detector and methane-loving life at the bottom of the Pacific ocean.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Rumours that fuelled the Great Fear in revolutionary France were transmitted similarly to a viral disease. Plus, glow-in-the-dark succulents and a new treatment for acne.

The secret to living well past 100 years old seems to be a healthy lifestyle and a lucky set of genes. Plus, a machine-learning tool reveals the research that might have never happened had the US National Institutes of Health’s current grant-cutting rationale been applied in 2014.

Astrocyte ‘support’ cells help engrave emotional memories on the brain in mice. Plus, what’s causing mysterious dots in images of the early universe and how making poison helped toads conquer the world.

A high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex from embryonic to postnatal development is presented, providing a real-time dynamic molecular map associated with individual cell types and specific developmental events.

Carbon emissions from individual energy giants can be directly linked to one quarter of heatwaves between 2000 and 2023. Plus, a brain ‘dial’ that turns the desire to eat on and off in mice and the researchers fighting back against the Trump administration’s assault on US science.

US climate scientists are rallying together to challenge a controversial government report on global warming. Plus, an exoplanet in the ‘Goldilocks’ zone of its star and why scientists glued a rubber duck to a rock.

A glowing marsupial and science-inspired Haute Couture are among the month’s sharpest science shots. Plus, ultra-processed foods could make it harder to shed weight and a scientific clash over bold ‘de-extinction’ claims.

Eighty years after the nuclear bombing of Hiroshima, there’s still lessons in the reflections of those that survived. Plus, an ancient plant tryst gave rise to modern potato tubers and how we can fix the peer-review crisis.

Supplements containing lithium seem to reverse the brain changes associated with Alzheimer’s disease in mice. Plus, the effect of genes can differ depending on their parent-of-origin and the teenage mathematician that disproved a 40-year-old conjecture.

A landmark court ruling could open the door for nations most affected by climate change to sue the most polluting countries. Plus, an artificial intelligence model that can predict lost Latin text and a fish-inspired medical device that sticks to slippery surfaces.

A Nature survey reveals that physicists disagree on even the basics of what quantum mechanics means in reality. Plus, sugars on a cell’s surface mapped at unprecedented resolution and the world’s wildest biology conference.

The aorta and other blood vessels seem to age more quickly than other organs. Plus, an unexpected ingredient in a Neanderthal’s diet and how developing food systems for space missions could benefit people on Earth.

Specialized immune cells in mice can act as ‘spies’ that help the brain control behaviours such as pursuit of food. Plus, publishing outside of your research field comes with a ‘pivot penalty’ and AI tools that can ‘hear’ signs of illness in a person’s voice.

Researchers have spotted a baby star at the beginning of its planet forming era. Plus, eight babies conceived via ‘three-person in vitro fertilization’ are living healthy lives and the best popular science and scholarly books to read now.

Research-integrity sleuths worry that their work is being used out of context to discredit long-held scientific knowledge. Plus, ancient proteins rewrite the evolutionary history of rhinos and a ‘super sponge’ material for sucking up carbon dioxide.

A trio of robots help each other abseil into lava tubes without human oversight. Plus, ‘sex-reversed’ birds are surprisingly common and the beginning of a new era for quantum-gravity research.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).