Nature Search

MaAsLin 3: refining and extending generalized multivariable linear models for meta-omic association discovery

MaAsLin 3 is a comprehensive and flexible framework for microbiome association studies with expanded toolsets of statistical models, tests and types of inference.

William A. Nickols
Thomas Kuntz
Curtis Huttenhower
ResearchOpen Access15 Jan 2026
Nature Methods

P: 1-11
Daily briefing: Cutting calories extends life — but not the way you think

The link between cutting down calories and a longer life might not be down to weight loss. Plus, get tips on how to keep research creativity flowing in management positions.

Jacob Smith
News10 Oct 2024
Nature
Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular subpopulations, flexibly overcoming enhanced β-lactams without new evolution and threatening the β-lactam pipeline.

Jacob E. Choby
Tugba Ozturk
David S. Weiss
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Superheating gold beyond the predicted entropy catastrophe threshold

Gold samples can be heated to more than 14 times their melting point while retaining their crystalline structure, far surpassing the predicted entropy catastrophe threshold and suggesting a substantially higher or potentially no limit for superheating.

Thomas G. White
Travis D. Griffin
Bob Nagler
ResearchOpen Access23 Jul 2025
Nature

Volume: 643, P: 950-954
Daily briefing: Avatar therapy helps people with psychosis stand up to the voices in their heads

Therapy using digital avatars could help people with psychosis hear fewer voices. Plus, we explore the growing field of RNA editing.

Jacob Smith
News29 Oct 2024
Nature
Author Correction: Microbiome differential abundance methods produce different results across 38 datasets

Jacob T. Nearing
Gavin M. Douglas
Morgan G. I. Langille
Amendments and CorrectionsOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome

Polygenic risk scores are nearing a level of differentiation required for their clinical utility in risk prediction in populations with high-risk rare pathogenic genetic variants.

Robert W. Davies
Ania M. Fiksinski
Jacob A. S. Vorstman
Research09 Nov 2020
Nature Medicine

Volume: 26, P: 1912-1918
Latent human herpesvirus 6 is reactivated in CAR T cells

Genomics analyses reveal that in vitro culture of CAR T cells can lead to reactivation of a latent herpesvirus, which might be involved in complications in patients receiving associated cell therapies.

Caleb A. Lareau
Yajie Yin
Ansuman T. Satpathy
Research08 Nov 2023
Nature

Volume: 623, P: 608-615
Microbiome differential abundance methods produce different results across 38 datasets

Many microbiome differential abundance methods are available, but it lacks systematic comparison among them. Here, the authors compare the performance of 14 differential abundance testing methods on 38 16S rRNA gene datasets with two sample groups, and show ALDEx2 and ANCOM-II produce the most consistent results.

Jacob T. Nearing
Gavin M. Douglas
Morgan G. I. Langille
ResearchOpen Access17 Jan 2022
Nature Communications

Volume: 13, P: 1-16
Deterministic direct reprogramming of somatic cells to pluripotency

This study shows that the combination of naive pluripotency growth conditions, Oct4, Sox2, Klf4 and Myc (OSKM) overexpression, and depleting the Mbd3/NuRD co-repressor results in deterministic and synchronized reprogramming to pluripotency.

Yoach Rais
Asaf Zviran
Jacob H. Hanna
Research18 Sept 2013
Nature

Volume: 502, P: 65-70
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-13
Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnostic assay to help identify pyrethroid-resistant strains.

Leon M. J. Mugenzi
Benjamin D. Menze
Charles S. Wondji
ResearchOpen Access11 Oct 2019
Nature Communications

Volume: 10, P: 1-11
Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria

Cells of the predatory bacterium Bdellovibrio bacteriovorus, which invades and replicates within the periplasm of other bacteria, have a characteristic curved rod shape. Here, Banks et al. show that a peptidoglycan hydrolase is required for the curved shape, and this facilitates invasion of prey cells.

Emma J. Banks
Mauricio Valdivia-Delgado
R. Elizabeth Sockett
ResearchOpen Access21 Mar 2022
Nature Communications

Volume: 13, P: 1-15
Energetic shifts reflect survival likelihood in Anopheles gambiae

Survival in Anopheles gambiae depends on resource use: survivors switch from carbohydrates to lipids, while non-survivors do not, revealing links between host energy allocation, parasite load, and coevolution.

Tiago G. Zeferino
Luís M. Silva
Jacob C. Koella
ResearchOpen Access12 Nov 2025
Communications Biology

Volume: 8, P: 1-8
Professional development programmes at world-class universities

W James Jacob
Weiyan Xiong
Huiyuan Ye
ResearchOpen Access27 Feb 2015
Palgrave Communications

Volume: 1, P: 1-27
RNA–lipid nanoparticles for acute critical illnesses

Beyond vaccines, RNA–lipid nanoparticle (LNP) nanomedicines have originally focused on cancer applications. This Review discusses how these therapeutics can also benefit acute critical illnesses (ACIs) owing to the short-term expression of mRNA while mitigating the adjuvant effect of LNPs, which, unlike in vaccines and cancer, can be a liability for ACIs.

Serena Omo-Lamai
Marco E. Zamora
Jacob S. Brenner
Reviews12 May 2025
Nature Reviews Bioengineering

Volume: 3, P: 775-790
Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer

Jacob T. Nearing
Vanessa DeClercq
Morgan G. I. Langille
ResearchOpen Access01 May 2023
npj Biofilms and Microbiomes

Volume: 9, P: 1-14
Progress and prospects in rat genetics: a community view

Timothy J Aitman
John K Critser
Kim Worley
Reviews28 Apr 2008
Nature Genetics

Volume: 40, P: 516-522
Heterotrophic bacterial diazotrophs are more abundant than their cyanobacterial counterparts in metagenomes covering most of the sunlit ocean

Tom O. Delmont
Juan José Pierella Karlusich
Eric Pelletier
Research25 Oct 2021
The ISME Journal

Volume: 16, P: 927-936
Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis

Amira D. Rghei
Jacob G. E. Yates
Sarah K. Wootton
Research02 Feb 2023
Gene Therapy

Volume: 32, P: 38-49
Ultrafast terahertz emission from emerging symmetry-broken materials

Insights from recent THz emission studies involving quantum materials and low-dimensional systems are surveyed from the standpoints of dynamical mechanisms and basic symmetries, highlighting interplays between intrinsic and designer structuring.

Jacob Pettine
Prashant Padmanabhan
Hou-Tong Chen
ReviewsOpen Access01 Jun 2023
Light: Science & Applications

Volume: 12, P: 1-30
Oral microbial signatures associated with age and frailty in Canadian adults

Vanessa DeClercq
Robyn J. Wright
Morgan G. I. Langille
ResearchOpen Access27 Apr 2024
Scientific Reports

Volume: 14, P: 1-14

Search

MaAsLin 3: refining and extending generalized multivariable linear models for meta-omic association discovery

Daily briefing: Cutting calories extends life — but not the way you think

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Superheating gold beyond the predicted entropy catastrophe threshold

Daily briefing: Avatar therapy helps people with psychosis stand up to the voices in their heads

Author Correction: Microbiome differential abundance methods produce different results across 38 datasets

Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome

Latent human herpesvirus 6 is reactivated in CAR T cells

Microbiome differential abundance methods produce different results across 38 datasets

Deterministic direct reprogramming of somatic cells to pluripotency

Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria

Energetic shifts reflect survival likelihood in Anopheles gambiae

Professional development programmes at world-class universities

RNA–lipid nanoparticles for acute critical illnesses

Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer

Progress and prospects in rat genetics: a community view

Heterotrophic bacterial diazotrophs are more abundant than their cyanobacterial counterparts in metagenomes covering most of the sunlit ocean

Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis

Ultrafast terahertz emission from emerging symmetry-broken materials

Oral microbial signatures associated with age and frailty in Canadian adults

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