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Advanced filters: Author: Jacqueline Plesset Clear advanced filters

Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

Simon and colleagues show that liver cancer cells undergo cell cycle arrest and senescence upon deprivation of methionine and identify GSK3 inhibitors as a senolytic to selectively deplete MAT2A inhibited senescent liver cancer cells.

Fuming Li
Pingyu Liu
M. Celeste Simon
Research02 Jan 2024
Nature Cancer

Volume: 5, P: 131-146
Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy

This protocol for CRISPR–Cas9 editing in primary mouse T cells enables studies of gene-edited CAR T cells in immune-intact cancer models, enabling users to explore the impact of a given gene deletion on CAR T cells within a natural tumor microenvironment.

Puneeth Guruprasad
Ranjani Ramasubramanian
Marco Ruella
Protocols25 Jul 2025
Nature Protocols

Volume: 20, P: 3629-3654

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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy

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