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Showing 101–150 of 371 results

Advanced filters: Author: Jae Hyun Han Clear advanced filters

A single-component, light-assisted uncaging switch for endoproteolytic release

Cui et al. developed LAUNCHER, a single-component switch using potyviral protease, which offers a high signal-to-noise ratio for precise payload release, enabling versatile cellular applications and enhanced synthetic circuit performance.

Mingguang Cui
Seunghwan Lee
Dongmin Lee
Research16 Nov 2023
Nature Chemical Biology

Volume: 20, P: 353-364
Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid droplets

Jinuk Kong
Yul Ji
Jae Bum Kim
ResearchOpen Access29 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

Akkermansia muciniphila produces P9, a small protein that interacts with intercellular adhesion molecule 2 to increase thermogenesis and glucagon-like peptide-1 secretion in mice.

Hyo Shin Yoon
Chung Hwan Cho
GwangPyo Ko
Research05 Apr 2021
Nature Microbiology

Volume: 6, P: 563-573
Soluble CD93 in allergic asthma

Hye Jung Park
Eun-Yi Oh
Jae-Hyun Lee
ResearchOpen Access15 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Early vascular aging determined by brachial-ankle pulse wave velocity and its impact on ischemic stroke outcome: a retrospective observational study

Minho Han
Jaeseob Yun
Hyo Suk Nam
ResearchOpen Access13 Jun 2024
Scientific Reports

Volume: 14, P: 1-8
Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis. Here, the authors study the roles played by 129 putative kinases in the growth and virulence of C. neoformans, identifying potential targets for development of anticryptococcal drugs.

Kyung-Tae Lee
Yee-Seul So
Yong-Sun Bahn
ResearchOpen Access28 Sept 2016
Nature Communications

Volume: 7, P: 1-16
An angle-compensating colorimetric strain sensor with wide working range and its fabrication method

Nguyen Hoang Minh
Kwanoh Kim
Jae Sung Yoon
ResearchOpen Access19 Dec 2022
Scientific Reports

Volume: 12, P: 1-10
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

Wei Zheng and colleagues report the results of a large-scale genome-wide association study of colorectal cancer in East Asians. They identify six new susceptibility loci, including variants near TCF7L2 and TGFB1.

Ben Zhang
Wei-Hua Jia
Wei Zheng
Research18 May 2014
Nature Genetics

Volume: 46, P: 533-542
Anion control as a strategy to achieve high-mobility and high-stability oxide thin-film transistors

Hyun-Suk Kim
Sang Ho Jeon
Kinam Kim
ResearchOpen Access15 Mar 2013
Scientific Reports

Volume: 3, P: 1-7
Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phases

Pil-Ryung Cha
Hyung-Seop Han
Hyun-Kwang Seok
ResearchOpen Access06 Aug 2013
Scientific Reports

Volume: 3, P: 1-6
Electronic Structure of the Kitaev Material α-RuCl₃ Probed by Photoemission and Inverse Photoemission Spectroscopies

Soobin Sinn
Choong Hyun Kim
Tae Won Noh
ResearchOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1-7
A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

Young Han Lee
Seung-Hyun Jeon
Soon Young Shin
ResearchOpen Access29 Feb 2012
Experimental & Molecular Medicine

Volume: 44, P: 369-377
Bias-voltage dependence of perpendicular spin-transfer torque in asymmetric MgO-based magnetic tunnel junctions

Spin-transfer torque allows the magnetization of nanopillar devices to be switched electrically. Incorporating asymmetries into the design of such a device generates a linear out-of-plane torque component that could help prevent the unwanted spontaneous reversal of the nanopillar’s magnetization.

Se-Chung Oh
Seung-Young Park
Kyung-Jin Lee
Research25 Oct 2009
Nature Physics

Volume: 5, P: 898-902
The regulatory role of ACP5 in the diesel exhaust particle-induced AHR inflammatory signaling pathway in a human bronchial epithelial cell line

Aaron Yu
Dankyu Yoon
Kyung-Rok Yu
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression

Exercise is helpful to counteract obesity and the related complications, and positive effects are associated to a switch of muscle fibres to an oxidative type. Here, the authors show that sirtuin 6 overexpression in mice induces such a switch by modulating Sox6 and CREB signalling, suggesting that sirtuin 6 may be a target for exercise mimetics.

Mi-Young Song
Chang Yeob Han
Byung-Hyun Park
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study

Chan Young Jeong
Gwang Hyeon Choi
Sook-Hyang Jeong
ResearchOpen Access31 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Association between regular walking and periodontitis according to socioeconomic status: a cross-sectional study

Su-Jin Han
Kwang-Hak Bae
Hyun-Jae Cho
ResearchOpen Access10 Sept 2019
Scientific Reports

Volume: 9, P: 1-7
Atherogenic index of plasma and coronary artery calcification progression beyond traditional risk factors according to baseline coronary artery calcium score

Ki-Bum Won
Donghee Han
Hyuk-Jae Chang
ResearchOpen Access07 Dec 2020
Scientific Reports

Volume: 10, P: 1-7
Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation

Eun-Young Kim
Eun-Na Lee
Sung-Joo Kim
ResearchOpen Access01 Jun 2006
Experimental & Molecular Medicine

Volume: 38, P: 284-294
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos to autophagosomal degradation.

Hyunjoo Cha-Molstad
Ji Eun Yu
Bo Yeon Kim
ResearchOpen Access24 Jul 2017
Nature Communications

Volume: 8, P: 1-17
Publisher Correction: A multicenter observational study to establish practice for circulatory death declaration for organ donation in South Korea

Han Young Lee
Jae-myeong Lee
Gil Myeong Seong
Amendments and CorrectionsOpen Access10 Dec 2024
Scientific Reports

Volume: 14, P: 1
Development and validation of an interpretable model for predicting sepsis mortality across care settings

Young Seok Lee
Seungbong Han
Hyung Koo Kang
ResearchOpen Access13 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Identification of Gng8-expressing cell types in the MHb and IPN

Hyun-ju Lee
Tae-Ik Choi
Insop Shim
Research27 Oct 2021
Molecular Psychiatry

Volume: 26, P: 3665
Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial role for it in maintaining brown adipocyte mitochondrial OXPHOS and thermogenesis upon cold stimulus.

Anna Park
Kwang-eun Kim
Jae Myoung Suh
ResearchOpen Access23 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse model of Alzheimer’s disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells.

Byung Jo Choi
Min Hee Park
Jae-sung Bae
ResearchOpen Access24 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Direct Observation of Localized Spin Antiferromagnetic Transition in PdCrO₂ by Angle-Resolved Photoemission Spectroscopy

Han-Jin Noh
Jinwon Jeong
Seongsu Lee
ResearchOpen Access14 Jan 2014
Scientific Reports

Volume: 4, P: 1-6
Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats

Yong-Han Paik
Young Joon Yoon
Kwang-Hyub Han
ResearchOpen Access18 Apr 2011
Experimental & Molecular Medicine

Volume: 43, P: 341-349
Myocardial infarction patients show altered lipoprotein properties and functions when compared with stable angina pectoris patients

Kyung-Hyun Cho
Dong-Gu Shin
Jae-Ryong Kim
ResearchOpen Access28 Feb 2009
Experimental & Molecular Medicine

Volume: 41, P: 67-76
Author Correction: Automated severity scoring of atopic dermatitis patients by a deep neural network

Chul Hwan Bang
Jae Woong Yoon
Ji Hyun Lee
Amendments and CorrectionsOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1
Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study

Mee Joo Kang
Jiwon Lim
Sang-Jae Park
ResearchOpen Access17 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction modulates the KRS-promoted metastatic potential of 67LR without disrupting the normal function of each protein.

Dae Gyu Kim
Jin Young Lee
Sunghoon Kim
Research10 Nov 2013
Nature Chemical Biology

Volume: 10, P: 29-34
Enantioselective sensing by collective circular dichroism

An array of 2D crystals of isotropic, 432-symmetric chiral gold nanoparticles is shown to exhibit collective resonances with a strong and uniform chiral near field, allowing enantioselective detection by the collective circular dichroism.

Ryeong Myeong Kim
Ji-Hyeok Huh
Ki Tae Nam
Research14 Dec 2022
Nature

Volume: 612, P: 470-476
Effects of human activities on Sericinus montela and its host plant Aristolochia contorta

Si-Hyun Park
Jae Hyun Kim
Jae Geun Kim
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-11
PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility

This study examines the contribution of a specific phosphatidylinositol 3-kinase (PI3K) isoform, namely PI3Kγ, to hippocampal synaptic plasticity and behavior. The authors find that the loss of PI3Kγ can specifically impair NMDA receptor–mediated long-term depression and cognitive functions that rely on behavioral flexibility.

Jae-Ick Kim
Hye-Ryeon Lee
Bong-Kiun Kaang
Research23 Oct 2011
Nature Neuroscience

Volume: 14, P: 1447-1454
Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Compulsivity is associated with many psychiatric disorders including obsessive compulsive disorder. However, the neural circuits that mediate this trait are not clearly defined. Here the authors show that the amygdalostriatal circuit plays a critical role in the pathophysiology of compulsive-like behavior.

In Bum Lee
Eugene Lee
Bong-June Yoon
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Automatic detection of mesiodens on panoramic radiographs using artificial intelligence

Eun-Gyu Ha
Kug Jin Jeon
Sang-Sun Han
ResearchOpen Access29 Nov 2021
Scientific Reports

Volume: 11, P: 1-8
Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia

Cheng-yun Jin
Jae-dong Lee
Gi-young Kim
Research01 Oct 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1645-1651
Linearly programmable two-dimensional halide perovskite memristor arrays for neuromorphic computing

This work presents a 7 × 7 crossbar array based on analog perovskite synapses and suggests that ion transport and interfacial barrier changes are more important than filaments with localized ions when constructing neuromorphic AI accelerators.

Seung Ju Kim
In Hyuk Im
Ho Won Jang
Research18 Oct 2024
Nature Nanotechnology

Volume: 20, P: 83-92
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids

The culture of gastrointestinal organoids relies on Matrigel that has several drawbacks for clinical application. Here, the authors report the feasibility of gastrointestinal tissue-mimetic matrices as effective alternatives to Matrigel for organoid culture and transplantation.

Suran Kim
Sungjin Min
Seung-Woo Cho
ResearchOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1-21
Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Mouse fibroblasts can be simultaneously directly reprogrammed into cardiomyocytes, endothelial cells and smooth muscle cells to form cardiac tissue structures that improve cardiac function on implantation into infarcted mouse hearts.

Jaeyeaon Cho
Sangsung Kim
Young-sup Yoon
Research23 Aug 2021
Nature Biomedical Engineering

Volume: 5, P: 880-896
Graphene nanopattern as a universal epitaxy platform for single-crystal membrane production and defect reduction

Epitaxy on nanopatterned graphene enables the realization of a broad spectrum of freestanding single-crystalline membranes with substantially reduced defects.

Hyunseok Kim
Sangho Lee
Jeehwan Kim
Research22 Sept 2022
Nature Nanotechnology

Volume: 17, P: 1054-1059
Corticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19

Hyun-Woo Jeong
Jeong Seok Lee
Eui-Cheol Shin
ResearchOpen Access20 Mar 2023
Experimental & Molecular Medicine

Volume: 55, P: 653-664
Maximum standardized uptake value on ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography improves outcome prediction in retroperitoneal liposarcoma

Jinsoo Rhu
Seung Hyup Hyun
Sung Joo Kim
ResearchOpen Access29 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma

Won-Suk Song
Hae-Min Park
Yun-Gon Kim
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-8
Benefit of Adjuvant Chemoradiotherapy in Resected Gallbladder Carcinoma

Tae Hyun Kim
Sang Myung Woo
Dae Yong Kim
ResearchOpen Access13 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Metabolites can regulate stem cell behavior through the STAT3/AKT pathway in a similar trend to that under hypoxic conditions

Gun-Jae Jeong
Donglim Kang
Dong-ik Kim
ResearchOpen Access16 Apr 2019
Scientific Reports

Volume: 9, P: 1-9
Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics

Hye Jung Park
Jung-Ho Sohn
Jae-Hyun Lee
ResearchOpen Access17 Jul 2015
Experimental & Molecular Medicine

Volume: 47, P: e173
Optimal blood pressure after reperfusion therapy in patients with acute ischemic stroke

Kang-Ho Choi
Jae-Myung Kim
Ki-Hyun Cho
ResearchOpen Access05 Apr 2019
Scientific Reports

Volume: 9, P: 1-8
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

Ju Youn Lee
Seung Hoon Han
Jae-sung Bae
ResearchOpen Access12 May 2020
Nature Communications

Volume: 11, P: 1-19
Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)⁺ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy expenditure by regulating hypothalamic NAD⁺ levels.

Jae Woo Park
Eun Roh
Min-Seon Kim
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-17

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