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Showing 1–8 of 8 results
Advanced filters: Author: Jagotamoy Das Clear advanced filters

  • A reagentless method for detecting analytes based on the motion of an inverted molecular pendulum has now been developed. The sensor is capable of detecting important physiological markers of stress, allergy, cardiovascular health, inflammation and cancer and works in blood, saliva, urine, tears and sweat. The sensor is also capable of collecting data in living animals.

    • Jagotamoy Das
    • Surath Gomis
    • Shana O. Kelley
    Research
    Nature Chemistry
    Volume: 13, P: 428-434

  • Exosomal PD-L1 (exoPD-L1) is a biomarker predicting immunotherapeutic responses. Here the authors report NanoEPIC, a nanoscale cytometry platform that enables phenotypic sorting and exoPD-L1 profiling from blood plasma by using magnetic-activated ranking to differentiate exosomal subpopulations.

    • Kangfu Chen
    • Bill T. V. Duong
    • Shana O. Kelley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Rapid, highly multiplexed molecular detection platforms may enable more specific and effective disease diagnosis. Here, a solution-based circuit is reported that enables the analysis of samples for panels of pathogens and antibiotic-resistance profiles at clinically relevant levels in less than 2 min.

    • Brian Lam
    • Jagotamoy Das
    • Shana O. Kelley
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Point-of-care analytical devices are of interest for diagnostic applications where larger scale laboratory instruments are not feasible or available. Here, the authors present a direct read-out colorimetric sensor which uses catalytic gas production to visualize picomolar concentrations of DNA.

    • Justin D. Besant
    • Jagotamoy Das
    • Shana O. Kelley
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • The analysis of circulating cell-free nucleic acids (cfNA) in the blood of cancer patients permits the analysis of tumour mutations without requiring invasive sampling of tissue. Now, the development of an electrochemical assay that uses a collection of clamp molecules to sequester interfering cfNAs enables the accurate detection of mutated sequences in serum collected from people with lung cancer or melanoma.

    • Jagotamoy Das
    • Ivaylo Ivanov
    • Shana O. Kelley
    Research
    Nature Chemistry
    Volume: 7, P: 569-575

  • A universal detector of small molecules, proteins and nucleic acids is described that relies on the displacement of a neutralizer molecule from a sensor surface. When the neutralizer is displaced by an analyte, an electrochemical signal is generated. Ultrasensitive limits of detection are achieved, and a new record for the electrochemical detection of bacteria (0.15 colony-forming units per microlitre) is reported.

    • Jagotamoy Das
    • Kristin B. Cederquist
    • Shana O. Kelley
    Research
    Nature Chemistry
    Volume: 4, P: 642-648

  • Continuous monitoring of diverse biomolecular signatures has the potential to transform our understanding of personalized and preventative medicine. This Review Article discusses the emerging trends and pertinent considerations for the development of a new generation of body-based biomolecular sensors for in vivo measurement.

    • Connor D. Flynn
    • Dingran Chang
    • Shana O. Kelley
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 560-575