Nature Search

An expanded registry of candidate cis-regulatory elements

The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

Jill E. Moore
Henry E. Pratt
Zhiping Weng
ResearchOpen Access07 Jan 2026
Nature

P: 1-10
Validation of histopathology-based deep learning algorithms for detection of actionable non-small cell lung cancer biomarkers

Christian Rolfo
Efrat Ofek
Iris Barshack
ResearchOpen Access20 Jan 2026
npj Precision Oncology

P: 1-12
The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation

The degradation of inner autophagosomal membranes remains poorly understood. Here, Makar et al. show that RNAseK is involved in a lysosomal hydrolase delivery pathway that contributes to autophagosomal membrane degradation.

Agata N. Makar
Alina Boraman
Noor Gammoh
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-16
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

Lysosomes maintain RPE health via TFEB/E3-regulated autophagy. Here, the authors show deregulated AKT2/SIRT5/TFEB signaling in the RPE inhibits both lysosomal and mitochondrial function and leads to AMD, suggesting this pathway might provide a therapeutic target for AMD.

Sayan Ghosh
Ruchi Sharma
Debasish Sinha
ResearchOpen Access21 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Apoptotic stress causes mtDNA release during senescence and drives the SASP

During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

Stella Victorelli
Hanna Salmonowicz
João F. Passos
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 627-636
Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

Gavert et al. develop an organotypic platform to define individual-specific therapies, show that it can reflect in vivo PDX responses and find that combined MEK and Src inhibition is effective in a large panel of human colorectal tumors.

Nancy Gavert
Yaara Zwang
Ravid Straussman
Research10 Feb 2022
Nature Cancer

Volume: 3, P: 219-231
High-efficiency base editing in the retina in primates and human tissues

A base-editing approach optimized to target the retina shows high editing rates in a mouse model of Stargardt disease, as well as in nonhuman primates and ex vivo human retinal explants, paving the way for potential clinical applications.

Alissa Muller
Jack Sullivan
Bence György
ResearchOpen Access08 Jan 2025
Nature Medicine

Volume: 31, P: 490-501
IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

Straussman and colleagues undertake clonal analyses and show that drug tolerance to EGFR therapy in lung cancer cell populations is an inherited continuous trait that is determined by IRS1 phosphorylation.

Adi Jacob Berger
Elinor Gigi
Ravid Straussman
Research21 Oct 2021
Nature Cancer

Volume: 2, P: 1055-1070
Increased Amazon carbon emissions mainly from decline in law enforcement

Comparison of the carbon balance during 2010–2018 with 2019 and 2020 shows that a decline in law enforcement may have led to an increase in Amazon forest carbon emissions.

Luciana V. Gatti
Camilla L. Cunha
Guilherme B. M. Machado
Research23 Aug 2023
Nature

Volume: 621, P: 318-323
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

Merbl and colleagues demonstrate that high expression of the proteasome regulator PSME4 is associated with immune-cold lung tumors and reduced antitumor immune responses, by functioning to modulate the protein degradome and antigen diversity.

Aaron Javitt
Merav D. Shmueli
Yifat Merbl
Research22 May 2023
Nature Cancer

Volume: 4, P: 629-647
The interaction of CD4⁺ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Amit and colleagues report that the specific interaction of a CD4⁺PD-1⁺CXCL13⁺ T-cell subset with antigen-presenting cells reprograms the tumor microenvironment and response to immune checkpoint inhibitors in non-small cell lung cancer.

Merav Cohen
Amir Giladi
Ido Amit
Research03 Mar 2022
Nature Cancer

Volume: 3, P: 303-317
Iridescence and hydrophobicity have no clear delineation that explains flower petal micro-surface

Jair E. Garcia
Mani Shrestha
Andrew D. Greentree
ResearchOpen Access30 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit

Yael Haberman
Iris Kamer
Jair Bar
ResearchOpen Access03 Feb 2023
Scientific Reports

Volume: 13, P: 1-12
Antimalarial drug discovery: progress and approaches

Malaria case numbers are rising globally and there is a vital need for new medicines that overcome the emergence of drug resistance. This Review describes the current landscape of small-molecule antimalarial therapies and the methods used to discover them as well as perspectives on approaches to find new targets and treatments.

Jair L. Siqueira-Neto
Kathryn J. Wicht
Elizabeth A. Winzeler
Reviews31 Aug 2023
Nature Reviews Drug Discovery

Volume: 22, P: 807-826
Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression

Antonia M. D. Churchhouse
Caroline V. Billard
Kevin B. Myant
ResearchOpen Access07 Sept 2024
Oncogene

Volume: 43, P: 3094-3107
Transcriptome-guided annotation and functional classification of long non-coding RNAs in Arabidopsis thaliana

Jose Antonio Corona-Gomez
Evelia Lorena Coss-Navarrete
Selene L. Fernandez-Valverde
ResearchOpen Access18 Aug 2022
Scientific Reports

Volume: 12, P: 1-16
Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference

Qing-Rong Liu
Ana Canseco-Alba
Emmanuel S. Onaivi
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-17
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

Nils Opel
Anbupalam Thalamuthu
Udo Dannlowski
ResearchOpen Access28 May 2020
Molecular Psychiatry

Volume: 26, P: 4839-4852
Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

Wendy Xin
Kornel E. Schuebel
Antonello Bonci
ResearchOpen Access13 Jul 2018
Neuropsychopharmacology

Volume: 44, P: 344-355
PulmonDB: a curated lung disease gene expression database

Ana B. Villaseñor-Altamirano
Marco Moretto
Alejandra Medina-Rivera
ResearchOpen Access16 Jan 2020
Scientific Reports

Volume: 10, P: 1-9
Blocking Zika virus vertical transmission

Pinar Mesci
Angela Macia
Alysson R. Muotri
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

Abraham Nunes
Hugo G. Schnack
Tomas Hajek
ResearchOpen Access31 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2130-2143
Attenuation of the p53 response to DNA damage by high cell density

Jair Bar
Efrat Cohen-Noyman
Moshe Oren
Research02 Feb 2004
Oncogene

Volume: 23, P: 2128-2137
Cancer cells suppress p53 in adjacent fibroblasts

J Bar
R Feniger-Barish
M Oren
Research08 Dec 2008
Oncogene

Volume: 28, P: 933-936
New ARCHITECT plasma pro-gastrin-releasing peptide assay for diagnosing and monitoring small-cell lung cancer

Benjamin Nisman
Hovav Nechushtan
Tamar Peretz
ResearchOpen Access26 Jan 2016
British Journal of Cancer

Volume: 114, P: 469-476

Search

An expanded registry of candidate cis-regulatory elements

Validation of histopathology-based deep learning algorithms for detection of actionable non-small cell lung cancer biomarkers

The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

High-efficiency base editing in the retina in primates and human tissues

IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

Increased Amazon carbon emissions mainly from decline in law enforcement

The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

The interaction of CD4⁺ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Iridescence and hydrophobicity have no clear delineation that explains flower petal micro-surface

Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit

Antimalarial drug discovery: progress and approaches

Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression

Transcriptome-guided annotation and functional classification of long non-coding RNAs in Arabidopsis thaliana

Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

PulmonDB: a curated lung disease gene expression database

Blocking Zika virus vertical transmission

Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

Attenuation of the p53 response to DNA damage by high cell density

Cancer cells suppress p53 in adjacent fibroblasts

New ARCHITECT plasma pro-gastrin-releasing peptide assay for diagnosing and monitoring small-cell lung cancer

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