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Mitochondrial proteostasis regulated by CRL5^Ozz and Alix modulates skeletal muscle metabolism and fiber type

In skeletal muscle mitochondria, CRL5^Ozz and Alix regulate the levels of the ATP transporter Slc25A4; loss of either protein in mice alters Slc25A4, causing mitochondrial defects, metabolic changes, and a shift from oxidative to glycolytic fibers.

Yvan Campos
Gustavo Palacios
Alessandra d’Azzo
ResearchOpen Access22 Dec 2025
Communications Biology

P: 1-22
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Environmental preference induced experimentally in ants (Hymenoptera: Formicidae)

Pierre Jaison
Research24 Jul 1980
Nature

Volume: 286, P: 388-389
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-15
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations.

Sanni E. Ruotsalainen
Ida Surakka
Samuli Ripatti
ResearchOpen Access17 Aug 2022
Communications Biology

Volume: 5, P: 1-16
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Max Tamlander et al. combine polygenic risk scores and clinical assessments to improve prediction of coronary artery disease and type 2 diabetes in European cohorts. Taken together, their results provide a useful method for preliminary cardiometabolic risk assessment in patients.

Max Tamlander
Nina Mars
Samuli Ripatti
ResearchOpen Access23 Feb 2022
Communications Biology

Volume: 5, P: 1-13

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Mitochondrial proteostasis regulated by CRL5^Ozz and Alix modulates skeletal muscle metabolism and fiber type

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Environmental preference induced experimentally in ants (Hymenoptera: Formicidae)

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

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Mitochondrial proteostasis regulated by CRL5Ozz and Alix modulates skeletal muscle metabolism and fiber type

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Environmental preference induced experimentally in ants (Hymenoptera: Formicidae)

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Search

Quick links

Mitochondrial proteostasis regulated by CRL5^Ozz and Alix modulates skeletal muscle metabolism and fiber type