Nature Search

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Mycoplanecins show promising activity against tuberculosis. Here, the authors identify and study mycoplanecins’ biosynthesis, antibacterial effects, and binding mechanism to DnaN, suggesting potential for fighting multidrug-resistant tuberculosis.

Chengzhang Fu
Yunkun Liu
Rolf Müller
ResearchOpen Access26 Jan 2024
Nature Communications

Volume: 15, P: 1-13
KCTD10 is a sensor for co-directional transcription–replication conflicts

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Jake A. Kloeber
Bin Chen
Zhenkun Lou
ResearchOpen Access08 Oct 2025
Nature

Volume: 648, P: 210-219
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and chaperone activity.

Levi J. McClelland
Kaiming Zhang
Stephen R. Sprang
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-10
Cloning and expression of human and rat Dt dopamine receptors

Qun-Yong Zhou
David K. Grandy
Olivier Civelli
Research06 Sept 1990
Nature

Volume: 347, P: 76-80
An allosteric modulator binds to a conformational hub in the β₂ adrenergic receptor

A negative allosteric modulator of the G-protein-coupled receptor β₂-adrenergic receptor binds to a membrane-facing surface adjacent to a molecular switch for receptor activation, and its binding disrupts a water-mediated polar network stabilizing an inactive switch conformation.

Xiangyu Liu
Jonas Kaindl
Peter Gmeiner
Research01 Jun 2020
Nature Chemical Biology

Volume: 16, P: 749-755
Self-renewing resident arterial macrophages arise from embryonic CX3CR1⁺ precursors and circulating monocytes immediately after birth

Macrophages densely populate the arterial wall, yet their origin and homeostasis are poorly understood. Robbins and colleagues show that arterial macrophages arise from CX3CR1⁺ embryonic precursors and adult bone marrow–derived monocytes that colonize the tissue immediately after birth.

Sherine Ensan
Angela Li
Clinton S Robbins
Research07 Dec 2015
Nature Immunology

Volume: 17, P: 159-168
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells

Klarissa Hollander
Swapnil C. Devarkar
Karen S. Anderson
ResearchOpen Access01 Sept 2025
npj Drug Discovery

Volume: 2, P: 1-15
Crystal structure of an Xrcc4–DNA ligase IV complex

Bancinyane L. Sibanda
Susan E. Critchlow
Luca Pellegrini
Research12 Nov 2001
Nature Structural Biology

Volume: 8, P: 1015-1019

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