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Showing 1–18 of 18 results
Advanced filters: Author: Jake W. O’Brien Clear advanced filters

  • The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.

    • Jinglong Li
    • Jake W. O’Brien
    • Kevin V. Thomas
    Research
    Nature Water
    Volume: 2, P: 1166-1177

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Wastewater-based epidemiology can be used to monitor viruses and chemical spread across diverse populations. Analysis of wastewater collected over 13 years from one treatment plant and from 51 wastewater treatment plants in 2021 shows the efficacy of the technique for studying the use of performance-enhancing substances.

    • Katja M. Shimko
    • Jake W. O’Brien
    • Kevin V. Thomas
    Research
    Nature Water
    Volume: 1, P: 879-886

  • About a quarter of the nitrogen added to the biosphere is exported from rivers to the ocean or inland basins, indicating substantial sinks for nitrogen must exist in the landscape. Data from nitrogen stable isotope tracer experiments across 72 streams suggests that the total uptake of nitrate is related to ecosystem photosynthesis, and that denitrification is related to ecosystem respiration. A stream network model demonstrates that excess nitrate in streams elicits a disproportionate increase in the fraction of nitrate that is exported to receiving waters and reduces the relative role of small versus large streams as nitrate sinks.

    • Patrick J. Mulholland
    • Ashley M. Helton
    • Suzanne M. Thomas
    Research
    Nature
    Volume: 452, P: 202-205

  • A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

    • Philippe Bégin
    • Jeannie Callum
    • Donald M. Arnold
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 2012-2024

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • The successful use of wastewater-based data during the COVID-19 pandemic has led to the creation of the National Wastewater Surveillance System in the USA for pathogen monitoring. Now a complementary system is needed for help tackling the opioid epidemic.

    • Fahad Ahmed
    • Jake W. O’Brien
    • Daniel A. Burgard
    Comments & Opinion
    Nature Water
    Volume: 1, P: 401-404

  • In atomic solids, substitutional doping is a powerful approach to modulating materials properties. Now, three substitutional mixtures of {Co6Se8} and {Cr6Te8} clusters in a crystal lattice with C60 fullerenes have been prepared. At two Co:Cr mixing ratios, the solid solutions showed particularly high electrical conductivities and low activation barriers for electron transport, owing to their structural heterogeneity.

    • Jingjing Yang
    • Jake C. Russell
    • Colin Nuckolls
    Research
    Nature Chemistry
    Volume: 13, P: 607-613

  • A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

    • Koen Alexander
    • Avishai Benyamini
    • Xinran Zhou
    ResearchOpen Access
    Nature
    Volume: 641, P: 876-883

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29