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Advanced filters: Author: Jakob Starzyk Clear advanced filters

Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration

Non-viral DNA donor templates are commonly used for targeted genomic integration via homologous recombination. Here the authors present the TESOGENASE system which enhances CRISPR-based gene integration by tethering circular single-stranded DNA to Cas9.

Hangu Nam
Keqiang Xie
Hao Wu
ResearchOpen Access16 May 2025
Nature Communications

Volume: 16, P: 1-14
Efficient non-viral immune cell engineering using circular single-stranded DNA-mediated genomic integration

CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function.

Keqiang Xie
Jakob Starzyk
Hao Wu
Research11 Dec 2024
Nature Biotechnology

Volume: 43, P: 1821-1832

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Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration

Efficient non-viral immune cell engineering using circular single-stranded DNA-mediated genomic integration

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