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Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation

Ancestral protein reconstruction of fructosamine kinase family reveals dynamic evolutionarily tuned allosteric network that modulates substrate selection through long-range intramolecular interactions in human FN3K.

Jenet K. Matlack
Robert E. Miner III
Jennifer M. Binning
ResearchOpen Access03 Apr 2026
Communications Biology

P: 1-9

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Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation

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