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PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

This study uses multi-omics approaches to dissect the roles of macrophage populations in the progression of metabolic dysfunction-associated steatohepatitis. GPNMB⁺ macrophages accumulate in the portal tract in advanced disease and may have antigen-presenting capabilities.

Having a rich negative emotion vocabulary is assumed to help cope with adversity. Here, the authors show that emotion vocabularies simply mirror life experiences, with richer negative emotion vocabularies reflecting lower mental health, and richer positive emotion vocabularies reflecting higher mental health.

A three-dimensional soft electronic sensor and stimulator array that is integrated with a three-dimensional cultured neural network can be used to record action potential from multiple planes over a period of 6 months, monitor evolving connectivity maps and pharmacological responses, as well as construct a reservoir neural network for biocomputing.

Climate and land-use change are transforming biodiversity, yet national futures remain uncertain. The study projects growing extinction debts, but suggests that sustainable low-emission pathways can limit the worst impacts on British biodiversity.

Manipulating chemical interactions is crucial in protein assembly. Here, the authors highlight the importance of accounting for solvent forces mediated by interfacial hydration structures when designing protein assemblies at liquid-crystal interfaces.

In a phase 1 basket trial, the small interfering RNA zodasiran, targeting ANGPTL3, lowered triglycerides in patients with severe hypertriglyceridemia and lowered both triglycerides and low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Bees are crucial for the maintenance of healthy ecosystems, yet rigorous estimates of their species’ richness are lacking. This study estimates taxonomic gaps for bees around the world and provides a standardised method for occurrence data.

Disentangling the exotic phases that can emerge at the surfaces of strongly correlated materials from the bulk is experimentally difficult. Here, Jain, Diao, Ong, Rusydi, and coauthors succeed in doing so, using grazing incident-angle dependent resonant X-ray scattering to find an emergent surface magnetic ordering and surface electronic dipole layers in the two-dimensional film of La2CuO4

Patient-derived xenografts are important tools for cancer drug development. Here, the authors develop models from 22 non-small cell lung cancer patients. They show genomic differences between models created from different spatial regions of tumours and a bottleneck on model establishment.

Nanocrystal assembly is key to creating complex architectures. Here, the authors show that tuning competitive ion adsorption alters anisotropic surface potentials and electrostatic torques, directing facet attachment to enable alternative mesoscale designs.

WHO STEPS survey data help assess global physical activity inequalities, and inform a new framework to recognize the impact of physical activity on health beyond cardiometabolic disease.

The Ocean Equity Index provides a systematic, twelve-criteria framework to assess and improve equity in ocean initiatives, projects and policies, producing structured data that guide evidence-based decisions and support more equitable outcomes for coastal communities and ecosystems.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

CellVoyager is an artificial intelligence agent capable of exploring new biological hypotheses by autonomously analyzing single-cell RNA sequencing datasets and accounting for background information and prior analyses.

Here, the authors show the mechanism by which Streptococcus pneumoniae can, through natural variation of a capsule transcriptional control element, alter capsule size and the course of serotype-specific infection with implications for vaccine escape.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

How the brain maintains object representations during grasping, when complex sensory input rapidly changes, remains poorly understood. Here the authors show that object-identity signals shift and strengthen across sensorimotor cortex as reaching transitions to grasping.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of complex behavioural traits.

Testing two families of large language models (LLMs) (GPT and LLaMA2) on a battery of measurements spanning different theory of mind abilities, Strachan et al. find that the performance of LLMs can mirror that of humans on most of these tasks. The authors explored potential reasons for this.

In a randomized controlled study at ICLR 2025, Thakkar et al. demonstrate that large language model-generated feedback can make reviews more informative while enhancing reviewer–author engagement.

In this Perspective, Hart et al. challenge recent NICE guidelines on suicide assessment, arguing that risk tools can promote health justice by prioritizing the worst-off and preventing indirect discrimination—especially for older adults.

This study shows that the intestine uses a specific pathway to generate the energy (ATP) needed to move dietary fat out of intestinal cells. A protein called ANKRD9 helps regulate this energy supply; without it, fat builds up in the intestine, and the body remains lean.

Diffusion models are reframed by developing a generative blood cell classifier that performs reliably in low-data regimes, adapts to domain shifts, detects anomalies with robustness and provides uncertainty estimates that surpass clinical expert benchmarks.

The adaptive capabilities of planktonic communities to climate change remain uncertain. Here, using Lagrangian particle tracking and network theory, the authors show that surface ocean currents can navigate the globe within 10 years, suggesting that marine plankton may keep pace with climate change.

A qualitative analysis of two decades of policy documents from 200 countries and interviews with 46 key informants found that adoption of policies to promote physical activity has increased since 2004, but implementation remains weak because physical activity is still a low, albeit gradually increasing, political priority in most countries.

Zero Invasive Predators (ZIP) is a New Zealand company working together with the New Zealand Department of Conservation and other organizations, community groups and Māori groups towards eradicating invasive predator species from the country. We spoke to James Russell, a professor at the University of Auckland and chief scientist at ZIP, and Maggie Nichols, a predator ecologist at ZIP, about the company’s work.

Early life RSV infection contributes to risk of childhood asthma. Here, the authors develop a statistical model to predict age at first RSV infection in the United States based on birthdate, demographics, and RSV surveillance data which could be used to identify groups at risk of chronic respiratory sequalae like asthma.

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A spatially resolved optical polarimetry technique is used to identify a three-state Potts-nematic order parameter in a triangular lattice antiferromagnetic material.

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Bicycling offers great benefits for urban residents in low- and middle-income countries, yet pathways to scale its adoption remain poorly understood. This study reveals the current state of bicycling infrastructure and policy, as well as key barriers, through fieldwork in four cities.

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.