Activation of CD4+ T cells leads to their polarization to various effector states. Goldrath and colleagues identify a role for the E-protein inhibitor Id2 in promoting TH1 cell polarization over TFH cell polarization. Reciprocally, the transcription factor Bcl-6 represses Id2 expression in TFH cells.
- Laura A Shaw
- Simon Bélanger
- Ananda W Goldrath