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JWST and Keck II spectral observations of Saturn’s moon Titan reveal methyl (CH₃) as well as non-local thermodynamic equilibrium emission bands of CO and CO₂. Imaging shows clouds in Titan’s northern hemisphere at several epochs, with some appearing to evolve in altitude.

Observations of optical flares from AT2022tsd (the ‘Tasmanian Devil’) show that they have durations on the timescale of minutes, occur over a period of months, are highly energetic, are probably nonthermal and have supernova luminosities.

SN 2022qmx, dubbed SN Zwicky, is a rare, gravitationally lensed type Ia supernova, magnified by a factor of 25, discovered by the Zwicky Transient Facility. Follow-up Keck observations reveal four multiple images with unusually small separation.

Application of multiancestry and ensemble-based approaches yields improved polygenic risk prediction models for breast cancer and its subtypes among women of African ancestry.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

JWST has detected \({{\rm{H}}}_{3}^{+}\) and auroral emissions at Neptune—the only giant planet in the Solar System for which they had proved to be elusive up to now. The observations reveal a factor-of-two cooling of Neptune’s upper atmosphere compared with Voyager 2 data, indicative of energy balance processes acting on a shorter timescale than solar forcing.

A nine-year transit-timing campaign has measured the extremely low masses and densities of four large planets orbiting the young star V1298 Tau, which are now predicted to contract and form a typical compact super-Earth and sub-Neptune system.

Analysis of the stellar population properties of 30 host galaxies of fast radio bursts (FRBs) suggests an abundance of FRBs in massive star-forming galaxies, and implies that the formation of FRB sources—magnetars—is linked to core-collapse supernovae of stellar merger remnants.

Using a large cosmological sample of FRBs, Connor et al. have located many of the Universe’s unseen baryons, finding that most reside in the diffuse intergalactic medium, not galaxies—confirming the strong astrophysical feedback seen in simulations.

The giant planet 8 Ursae Minoris b seems to have avoided engulfment by its giant host star through a stellar merger that either affected the evolution of the host star or produced 8 Ursae Minoris b as a second-generation planet.

A series of early-time, multiwavelength observations of an optical transient, AT2022cmc, indicate that it is a relativistic jet from a tidal disruption event originating from a supermassive black hole.

The visible–near-infrared spectrum of the dark spot that appeared on Neptune in 2018 indicates the presence of material that makes the aerosol layer at 5 bar darker at visible wavelengths. Such material can come from deeper layers via upwelling or by sublimation of H₂S ice that reveals the darker condensation nuclei.

Observations and stellar evolution models of a blue ring nebula and its central star (TYC 2597-735-1) suggest that the remnant star merged with a lower-mass companion several thousand years ago.

The Zwicky Transient Facility has observed a transitioning white dwarf with two faces, with one side of its atmosphere dominated by hydrogen and the other by helium.

Methane emission from a very cool brown dwarf, perhaps arising from an aurora, has been detected in James Webb Space Telescope observations.

A combination of JWST/NIRCam observations and magnetohydrodynamic simulations indicates that frequent mergers with close companions give rise to bursty star formation and hence the unexpectedly high Lyman-α emission detected from early galaxies.

Warm Atlantic Water was a major driver of both initial NEGIS retreat from 21.6 ka BP and the collapse of its ice shelf ~15.2 ka BP. This study demonstrates the key role of ice-ocean interactions in controlling ice-sheet retreat.

Spectroscopy of a gravitationally lensed galaxy at a redshift of 2.7 with spatially resolved maps of two foreground damped Lyman α systems indicates a vast mass of neutral hydrogen gas, consistent with a star-forming region.

A purpose-built instrument to detect the faint emission lines of the Lyman-α forest provides evidence of filaments that connect galaxies and trace the cosmic web.

LTT 9779 b is Neptune-sized planet rotating around its star with a period of 0.79 days and an equilibrium temperature of 2,000 K. It is not clear how it retained its atmospheric envelope, which contains ~10% of H/He, as it should have been photoevaporated by now.

Theory predicts that winds expel baryons from galaxies into intergalactic space; now optical observations of the massive, but compact, galaxy SDSS J211824.06+001729.4 show that it is ejecting an enormous ionized outflow of gas.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

We find that the optical emission due to ionized gas that is characteristic of a shock extends 40 kpc in diameter across the host galaxy of an odd radio circle.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Both Earth and Jupiter have equatorial oscillations in their atmospheres. An analysis of over two decades of observations of Saturn's stratospheric emission finds a similar oscillation. The period is 14.8 ± 1.2 terrestrial years, roughly half of Saturn's year, suggesting the influence of seasonal forcing, as is the case with the Earth's semi-annual oscillation.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Multiwavelength observations of a galactic nucleus exhibit quasi-periodic X-ray eruptions (QPEs) that repeat every 22 days, a timescale intermediate between those of other QPEs and so-called repeating nuclear transients. The eruptions are likely to be driven by the interaction between an orbiting body and a central massive black hole.

Two nearby black holes are the most massive yet found, with masses—of around ten billion solar masses—considerably greater than predicted by conventional methods relating black-hole mass with the stellar velocity dispersion and bulge luminosity of the host galaxy.

Lee et al. uncover a previously uncharacterized role of OASL in virus-induced necroptosis. OASL chaperones the assembly of RIPK3 and ZBP1 via liquid-liquid phase separation, which induces RIPK3 and necroptosis activation, thereby modulating inflammation and host defence against viral infection.

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Nulling interferometry is a technique combining lights from different telescopes or apertures to observe weak sources nearby bright ones. The authors report the first nulling interferometer implemented in a photonic chip doing spectrally dispersed nulling on several baselines, simultaneously.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A two-dimensional spectroscopic investigation of a large, luminous filament of the cosmic web near QSO UM287 reveals that the brightest emission region is an extended rotating hydrogen disk with a velocity profile that is characteristic of gas in a 10¹³-solar-mass dark-matter halo, with a geometry that is strongly suggestive of cold flow accretion.

Radio and optical spectroscopic observations of a brown dwarf reveal auroral emissions powered by magnetospheric currents, showing that aurorae may be a signature of magnetospheres much larger than those observed in our Solar System.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Multi-instrument detection of a nearby type 1a supernova shows that the exploding star was probably a carbon–oxygen white dwarf star in a binary system with a main-sequence companion.

The tidal disruption event AT2019dsg is probably associated with a high-energy neutrino, suggesting that such events can contribute to the cosmic neutrino flux. The electromagnetic emission is explained in terms of a central engine, a photosphere and an extended synchrotron-emitting outflow.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

2M1510 is an approximately 45-million-year-old triple system of brown dwarfs, two of which form a close binary in a 20-day orbit and have almost the same mass (3.82% and 3.75% of the mass of the Sun, respectively). Their physical parameters are in good agreement with evolutionary models except for luminosity, suggesting that we might be underestimating the masses of brown dwarfs and massive exoplanets by about 30%.

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Multi-wavelength data from a cluster–cluster merger reveals that relativistic electrons ejected from near an actively accreting black hole are efficiently re-accelerated at a cluster shock to produce characteristically diffuse radio emission.