Nature Search

Primary structure and expression of bovine poly(A) polymerase

Tobias Raabe
F. J. Bollum
James L. Manley
Research19 Sept 1991
Nature

Volume: 353, P: 229-234
Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

Jian Wu
James L. Manley
Research29 Aug 1991
Nature

Volume: 352, P: 818-821
The Maritime Uplands of Britain : Inventory and Prospect

JAMES A. TAYLOR
Research18 Mar 1961
Nature

Volume: 189, P: 872-876
Cell-cycle related regulation of poly(A) polymerase by phosphorylation

Diana Foukal Colgan
K. G. K. Murthy
James L Manley
Research21 Nov 1996
Nature

Volume: 384, P: 282-285
A polyadenylation factor subunit is the human homologue of theDrosophila suppressor of forked protein

Yoshio Takagaki
James L. Manley
Research01 Dec 1994
Nature

Volume: 372, P: 471-474
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Jhumku D. Kohtz
Sharon F. Jamison
James L. Manley
Research10 Mar 1994
Nature

Volume: 368, P: 119-124
Synthesis in vitro of an exceptionally long RNA transcript promoted by an AluI sequence

James L. Manley
Mary T. Colozzo
Research25 Nov 1982
Nature

Volume: 300, P: 376-379
Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

Christopher W. J. Smith
Elena B. Porro
Bernardo Nadal-Ginard
Research16 Nov 1989
Nature

Volume: 342, P: 243-247
Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells

E. Diann Lewis
James L. Manley
Research12 Sept 1985
Nature

Volume: 317, P: 172-175
Drosophila Krüppel protein is a transcriptional represser

Jonathan D. Licht
Martha J. Grossel
Ulla M. Hansen
Research05 Jul 1990
Nature

Volume: 346, P: 76-79
Interaction between a transcriptional activator and transcription factor IIB in vivo

John Colgan
Sharon Wampler
James L. Manley
Research08 Apr 1993
Nature

Volume: 362, P: 549-553
Cloning and domain structure of the mammalian splicing factor U2AF

Phillip D. Zamore
James G. Patton
Michael R. Green
Research13 Feb 1992
Nature

Volume: 355, P: 609-614
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Crystal structure of the DsbA protein required for disulphide bond formation in vivo

Jennifer L. Martin
James C. A. Bardwell
John Kuriyan
Research30 Sept 1993
Nature

Volume: 365, P: 464-468
Determination of Heats of Adsorption by Transient-Response Techniques

JAMES J. CARBERRY
Research04 Feb 1961
Nature

Volume: 189, P: 391-393
Single myosin molecule mechanics: piconewton forces and nanometre steps

Jeffrey T. Finer
Robert M. Simmons
James A. Spudich
Research10 Mar 1994
Nature

Volume: 368, P: 113-119
Spliced leader RNAs from lower eukaryotes are trans- spliced in mammalian cells

James P. Bruzik
Tom Maniatis
Research17 Dec 1992
Nature

Volume: 360, P: 692-695
Erythroid-specific transcription of the chicken histone H5 gene is directed by a 3′ enhancer

Cecelia D. Trainor
Susan J. Stamler
James Douglas Engel
Research27 Aug 1987
Nature

Volume: 328, P: 827-830
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity

Regulator of transcription 1, Rtr1, has been proposed to function as an RNA polymerase II phosphatase. Here, the lack of phosphatase activity in purified Rtr1 and the absence of an active site in the structure of the yeast protein suggest that Rtr1 does not dephosphorylate RNA polymerase II.

Kehui Xiang
James L. Manley
Liang Tong
Research10 Jul 2012
Nature Communications

Volume: 3, P: 1-6
Splicing-related catalysis by protein-free snRNAs

Saba Valadkhan
James L. Manley
Research18 Oct 2001
Nature

Volume: 413, P: 701-707
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

Ellis J. Neufeld
David G. Skalnik
Stuart H. Orkin
Research01 Apr 1992
Nature Genetics

Volume: 1, P: 50-55
Plasmid-mediated tissue invasiveness in Yersinia enterocolitica

Don L. Zink
James C. Feeley
Gerard A. O'Donovan
Research10 Jan 1980
Nature

Volume: 283, P: 224-226
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

Ke Wang
Amit Goldenberg
Hannah Moshontz
Research02 Aug 2021
Nature Human Behaviour

Volume: 5, P: 1089-1110
CD22 regulates thymus-independent responses and the lifespan of B cells

Kevin L. Otipoby
Kristin B. Andersson
Edward A. Clark
Research26 Dec 1996
Nature

Volume: 384, P: 634-637
An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing

Deming Xu
Shahrzad Nouraini
James D. Friesen
Research20 Jun 1996
Nature

Volume: 381, P: 709-713
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos

V. Danial Fitzpatrick
Anthony Percival-Smith
Henry M. Krause
Research16 Apr 1992
Nature

Volume: 356, P: 610-612
DNA antisense therapy for asthma in an animal model

Jonathan W. Nyce
W. James Metzger
Research20 Feb 1997
Nature

Volume: 385, P: 721-725
Coherent terahertz radiation with 2.8-octave tunability through chip-scale photomixed microresonator optical parametric oscillation

High-spectral-purity frequency-agile room-temperature THz sources are foundational elements for imaging, sensing, metrology, and communications. Here a parametric oscillator-photomixer chip with coherent 2.8-octave tunable THz radiation is achieved.

Wenting Wang
Ping-Keng Lu
Chee Wei Wong
ResearchOpen Access31 Aug 2022
Nature Communications

Volume: 13, P: 1-9
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Correction: Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued

Erika L. F. Holzbaur,
James A. Hammarback
Richard B. Vallee
Amendments and Corrections17 Dec 1992
Nature

Volume: 360, P: 695
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Global hotspots of mycorrhizal fungal richness are poorly protected

Machine-learning algorithms trained on 25,000 geolocated soil samples are used to create high-resolution global maps of mycorrhizal fungi, revealing that less than 10% of their biodiversity hotspots are in protected areas.

Michael E. Van Nuland
Colin Averill
Johan van den Hoogen
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 414-422
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Alternative splicing is an important gene regulatory mechanism for generating proteomic diversity, which markedly affects human development and is misregulated in many human diseases. Alternative splicing can be regulated at different stages of spliceosome assembly and by different mechanisms.

Mo Chen
James L. Manley
Reviews23 Sept 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 741-754
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Erratum: Intrinsic metal binding by a spliceosomal RNA

Saba Valadkhan
James L. Manley
Amendments and Corrections01 Sept 2002
Nature Structural Biology

Volume: 9, P: 711
Activator's target in sight

James W. Lillie
Michael R. Green
News & Views28 Sept 1989
Nature

Volume: 341, P: 279-280
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

SRp38, unlike other SR proteins, functions as a general splicing repressor when it is dephosphorylated. When phosphorylated it functions as a sequence-specific splicing activator and also affects the selection of mutually exclusive exons in the GluR-B pre-mRNA. Thus, SRp38 is a previously uncharacterized kind of splicing factor that can switch from a repressor to an activator and regulator of alternative splicing.

Ying Feng
Mo Chen
James L Manley
Research14 Sept 2008
Nature Structural & Molecular Biology

Volume: 15, P: 1040-1048
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Cell signalling and the control of pre-mRNA splicing

Chanseok Shin
James L. Manley
Reviews01 Sept 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 727-738
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

Alternative splicing of the pyruvate kinase M (PKM) pre-mRNA, resulting in the exclusion of either exon 9 or 10, requires a small set of splicing factors, hnRNPA1, hnRNPA2 and PTB. A new study reveals that these general splicing factors function through a concentration-dependent mechanism, coupled with nonsense-mediated decay, to determine the outcome of PKM pre-mRNA splicing.

Mo Chen
Charles J David
James L Manley
Research05 Feb 2012
Nature Structural & Molecular Biology

Volume: 19, P: 346-354
Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.

Larry C. Cheng
Dinghai Zheng
Bin Tian
ResearchOpen Access23 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

Yingwu Xu
Xiao Tao
Liang Tong
Research02 Nov 2000
Nature

Volume: 408, P: 111-115
Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

Xrn1 is a 5′-3′ exoribonuclease that is implicated in a range of regulated mRNA decay processes in eukaryotes. The structure of Xrn1 is now presented, indicating that it unexpectedly carries repeated structural domains with similarities to the Tudor, Chromo and other domains. These may stabilize the active site and form a platform for protein recruitment.

Jeong Ho Chang
Song Xiang
Liang Tong
Research06 Feb 2011
Nature Structural & Molecular Biology

Volume: 18, P: 270-276

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