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Thermoelectricity due to the interplay of the nonlocal Cooper pair splitting and the elastic co-tunneling in normal metal-superconductor-normal metal structure is predicted. Here, the authors observe the non-local Seebeck effect in a graphene-based Cooper pair splitting device.

Although quantum phase transitions are attracting increasing attention as the conceptual link between conventional and exotic states of quantum matter—having been implicated, for example, in the properties of high-temperature superconductors—there are few model systems in which they can be studied and understood. Now it is revealed that placing simple elemental chromium under pressure suppresses its normal magnetic state and gives direct experimental access to the underlying quantum phase transition responsible for these changes.

Natural Killer cells are key mediators of anti-tumour immunosurveillance and anti-viral immunity. Here, the authors map regulatory genetic variation in primary Natural Killer cells, providing new insights into their role in human health and disease.

This Review highlights chip-scale superconducting coherent photon source technologies and their rich potential as an important integrated quantum hardware to advance quantum information processing and communication networks.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Here a general, thermally driven and scalable method for reductive initiation is reported, in which inexpensive azo initiators are reacted with formate salts to form a carbon dioxide radical anion.

Materials that exhibit topologically protected electronic structures are expected to enable the development of more efficient spintronic devices. He et al.suggest that combining a quantum anomalous Hall insulator with a superconductor could be used to generate correlated spin currents.

The dynamical phases of out-of-equilibrium Bardeen–Cooper–Schrieffer superconductors have been simulated using cold atoms levitated inside an optical cavity.

Strange metallicity—in particular, resistance that is linear in temperature and magnetic field—is observed in a nanopatterned YBa₂Cu₃O_7−δ bosonic system.

Antimicrobial resistance poses a significant global health threat, necessitating swift and precise diagnostic solutions. Here, the authors introduce a culture-free diagnostic platform integrating microfluidic cell enrichment, single-cell Raman spectroscopy, and deep learning, that identifies bacterial and fungal infections directly from clinical samples within 20 minutes.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A superconducting diode effect is observed at zero magnetic field in twisted trilayer graphene. This suggests that time-reversal symmetry is intrinsically broken and leads to pairing between electrons with non-zero centre-of-mass momentum.

Atomic-resolution scanned Josephson tunnelling microscopy on multigap superconductor FeSe single crystals is studied, demonstrating condensate-resolved imaging and tuning capabilities.

The mitochondrial β-barrel assembly machinery exhibits conformational dynamics in the absence of substrate. The antibiotic darobactin A stabilizes the open confirmation of the Sam50 lateral gate and inhibits SAM complex function in vitro.

Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subsequent neutrophil effector functions.

The authors theoretically predict a superconducting diode effect in chiral nanotubes when a magnetic field is applied along the axis of the tube, where the diode efficiency is controlled by nanotube diameter and chiral angle. They further predict a non-reciprocal paraconductivity slightly above the superconducting transition temperature.

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Kagome metals continue to attract interest due to the coexistence of electronic correlations and band topology. Here the authors use proton gating to modulate disorder and carrier density in CsV₃Sb₅ nanoflakes, and show its effect on superconductivity, charge density wave and anomalous Hall effect.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Patients with inflammatory bowel disease (IBD) have increased risk for venous thromboembolism, but mechanistic insight is still lacking. Using both mouse experimental colitis models and IBD patient biopsies, here the authors implicate increased tissue factor activity on colitogenic T cells as a potential link.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Combining liquid crystals and nanocrystals functionalized with promesogenic ligands yields an interstitial colloidal solid solution exhibiting high thermal expansivity and reversible superlattice phase transitions driven by mesogen diffusion.

Data obtained from the MicroBooNE liquid-argon time projection chamber are used to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level.

Moisture-driven environmental changes in the terminal Pleistocene contributed to megafaunal extinction across four continents, as indicated by stable isotope analysis. Stable grasslands in Africa help to explain maintenance of African megafaunal populations.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

An extreme Einstein ring ~10,000 times as bright as the Milky Way in the infrared is studied with VLT/ERIS and ALMA, and the authors find that the lensed galaxy is a starburst with a fast-rotating disk, rather than being driven by a major merger.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.