Nature Search

Confined subsurface microbial communities in Cretaceous rock

Lee R. Krumholz
James P. McKinley
Joseph M. Suflita
Research06 Mar 1997
Nature

Volume: 386, P: 64-66
Coarse-grained fundamental forms for characterizing isometries of trapezoid-based origami metamaterials

The authors investigate the mechanical behavior of origami tessellations composed of trapezoid faces, which are more general but less studied compared to parallelogram faces. They develop analytical expressions for the deformation modes and test the model’s validity through laboratory scale experiments.

James P. McInerney
Diego Misseroni
Xiaoming Mao
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Maria Zanti
Denise G. O’Mahony
Kyriaki Michailidou
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-18
Why prokaryotes have pangenomes

Amalgamation of population genetic theory and models of horizontal gene transfer suggest that pangenomes in prokaryotes result from adaptive, not neutral, evolution.

James O. McInerney
Alan McNally
Mary J. O'Connell
Reviews28 Mar 2017
Nature Microbiology

Volume: 2, P: 1-5
The hybrid nature of the Eukaryota and a consilient view of life on Earth

McInerney and colleagues summarize the phylogenetic, cell biological, population biology, biochemical and paleontological evidence that cellular life consists of two primary, paraphyletic, prokaryotic groups and one secondary, monophyletic group that has symbiogenic origins — the eukaryotes.

James O. McInerney
Mary J. O'Connell
Davide Pisani
Reviews12 May 2014
Nature Reviews Microbiology

Volume: 12, P: 449-455
Ghost locus appears

The sequences of two sponge genomes provide evidence that the ParaHox developmental genes are older than previously thought. This has implications for animal taxonomy and for developmental and evolutionary biology. See Letter p.620

James O. McInerney
Mary J. O'Connell
News & Views29 Oct 2014
Nature

Volume: 514, P: 570-571
Mind the gaps in cellular evolution

Eukaryotic cells, with complex features such as membrane-bound nuclei, evolved from prokaryotic cells that lack these components. A newly identified prokaryotic group reveals intermediate steps in eukaryotic-cell evolution. See Article p.353

James O. McInerney
Mary J. O'Connell
News & Views11 Jan 2017
Nature

Volume: 541, P: 297-299
Origins of major archaeal clades correspond to gene acquisitions from bacteria

A comparison of protein-coding genes from 134 archaeal genomes with their homologues in 1,847 bacterial genomes reveals that, during evolution, genes are transferred more often from bacteria to archaea than vice versa, and that gene influxes from bacteria can bring about the origin of major archaeal groups.

Shijulal Nelson-Sathi
Filipa L. Sousa
William F. Martin
Research15 Oct 2014
Nature

Volume: 517, P: 77-80
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Building dementia knowledge globally through the Understanding Dementia Massive Open Online Course (MOOC)

Claire Eccleston
Kathleen Doherty
Fran McInerney
ResearchOpen Access10 Apr 2019
npj Science of Learning

Volume: 4, P: 1-6
Endosymbiotic origin and differential loss of eukaryotic genes

Eukaryotes acquired their prokaryotic genes in two episodes of evolutionary influx corresponding to the origin of mitochondria and plastids, respectively, followed by extensive differential gene loss, uncovering a massive imprint of endosymbiosis in the nuclear genomes of complex cells.

Chuan Ku
Shijulal Nelson-Sathi
William F. Martin
Research19 Aug 2015
Nature

Volume: 524, P: 427-432
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Previous studies identified an association between the 2q35 locus and breast cancer. Here, the authors show that a SNP at 2q35, rs4442975, is associated with oestrogen receptor positive disease and suggest that this effect is mediated through the downregulation of a known breast cancer gene, IGFBP5.

Maya Ghoussaini
Stacey L. Edwards
Anna De Fazio
Research23 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Impact-related microspherules in Late Pleistocene Alaskan and Yukon “muck” deposits signify recurrent episodes of catastrophic emplacement

Jonathan T. Hagstrum
Richard B. Firestone
Ted E. Bunch
ResearchOpen Access30 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Aflibercept in clinical practice; visual acuity, injection numbers and adherence to treatment, for diabetic macular oedema in 21 UK hospitals over 3 years

S. J. Talks
I. Stratton
Haralabos Eleftheriadis
ResearchOpen Access09 Jul 2021
Eye

Volume: 36, P: 72-77
Microbial mutualism dynamics governed by dose-dependent toxicity of cross-fed nutrients

Breah LaSarre
Alexandra L McCully
James B McKinlay
Research29 Nov 2016
The ISME Journal

Volume: 11, P: 337-348
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function

Claudio R. Cortés
Aideen M. McInerney-Leo
Carol Wicking
ResearchOpen Access20 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Rare germline copy number variants (CNVs) and breast cancer risk

Dennis et al. investigate potential breast cancer associations with rare germline copy number variants (CNVs) by conducting a genome-wide analysis in a large breast cancer case-control dataset. The authors detected associations with exonic deletions in established breast cancer susceptibility genes and suggestive associations for a number of non-coding CNVs.

Joe Dennis
Jonathan P. Tyrer
Douglas F. Easton
ResearchOpen Access18 Jan 2022
Communications Biology

Volume: 5, P: 1-15
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi
Jonathan Beesley
Alison M. Dunning
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Book Reviews

Robert Plomin
John Manning
James O Mcinerney
Books & Arts01 Jul 1998
Heredity

Volume: 81, P: 120-124
Function-related replacement of bacterial siderophore pathways

Hilke Bruns
Max Crüsemann
Nadine Ziemert
ResearchOpen Access15 Aug 2017
The ISME Journal

Volume: 12, P: 320-329

Search

Confined subsurface microbial communities in Cretaceous rock

Coarse-grained fundamental forms for characterizing isometries of trapezoid-based origami metamaterials

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

Why prokaryotes have pangenomes

The hybrid nature of the Eukaryota and a consilient view of life on Earth

Ghost locus appears

Mind the gaps in cellular evolution

Origins of major archaeal clades correspond to gene acquisitions from bacteria

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Building dementia knowledge globally through the Understanding Dementia Massive Open Online Course (MOOC)

Endosymbiotic origin and differential loss of eukaryotic genes

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Impact-related microspherules in Late Pleistocene Alaskan and Yukon “muck” deposits signify recurrent episodes of catastrophic emplacement

Aflibercept in clinical practice; visual acuity, injection numbers and adherence to treatment, for diabetic macular oedema in 21 UK hospitals over 3 years

Microbial mutualism dynamics governed by dose-dependent toxicity of cross-fed nutrients

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

CYP3A71C* allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Rare germline copy number variants (CNVs) and breast cancer risk

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Book Reviews

Function-related replacement of bacterial siderophore pathways

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