Here, the authors elucidate TMPRSS2 protease recognition of the SARS-CoV-2 spike S2′ cleavage site, revealing the molecular basis of activation of membrane fusion, and show that antibodies recognizing the S2′ site or TMPRSS2 block viral entry by interfering with TMPRSS2 access.
- Matthew McCallum
- James Brett Case
- David Veesler
