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Showing 1–24 of 24 results
Advanced filters: Author: Jamie O. Brett Clear advanced filters

  • De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

    • Mathieu Quinodoz
    • Kim Rodenburg
    • Carlo Rivolta
    ResearchOpen Access
    Nature Genetics
    Volume: 58, P: 169-179

  • Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

    • Alec Eickbusch
    • Matt McEwen
    • Alexis Morvan
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 1994-2001

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

    • Dmitry A. Abanin
    • Rajeev Acharya
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 646, P: 825-830

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.

    • Jamie L. Everman
    • Satria P. Sajuthi
    • Max A. Seibold
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • During ageing, S-adenosylmethionine (SAM) is depleted from muscle stem cells (MuSCs) because of increased synthesis of the polyamine spermidine, leading to loss of heterochromatin and dysfunction of MuSCs. SAM restoration rescues the mouse MuSC defects.

    • Jengmin Kang
    • Daniel I. Benjamin
    • Thomas A. Rando
    Research
    Nature Metabolism
    Volume: 6, P: 153-168

  • The genetic and epigenetic predisposition of bilateral Wilms tumour remains to be investigated. Here, the authors perform multiomics analysis and identify the predominant genetic and epigenetic events associated with bilateral Wilms tumour predisposition.

    • Andrew J. Murphy
    • Changde Cheng
    • Xiang Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

    • Rajeev Acharya
    • Dmitry A. Abanin
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 638, P: 920-926

  • Oligodendrocytes produce myelin in the central nervous system and can regenerate in adults. Brunet and colleagues show that inactivation of SIRT1 deacetylase increases the proliferation of oligodendrocyte progenitors partly by shifting other neural stem cells to this fate. Using genome-wide approaches, they delineate PDGFRα as a critical target of SIRT1 in its negative effects on oligodendrocyte lineage.

    • Victoria A. Rafalski
    • Peggy P. Ho
    • Anne Brunet
    Research
    Nature Cell Biology
    Volume: 15, P: 614-624

  • In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

    • Florian Leuschner
    • Partha Dutta
    • Matthias Nahrendorf
    Research
    Nature Biotechnology
    Volume: 29, P: 1005-1010

  • Extreme temperatures and fluid pressures are measured, and their causes modelled, in a borehole into the Alpine Fault, where an earthquake rupture is expected within the next few decades.

    • Rupert Sutherland
    • John Townend
    • Martin Zimmer
    Research
    Nature
    Volume: 546, P: 137-140

  • Multiple climate-related coastal hazards could impact people, infrastructure and ecosystems, yet previous works often focused on flooding only. By analysing the future exposure to four types of hazard along the US Southeast Atlantic coast, this research emphasizes the risks beyond flooding.

    • Patrick L. Barnard
    • Kevin M. Befus
    • Jamie L. Jones
    Research
    Nature Climate Change
    Volume: 15, P: 101-109

  • A mouse study reveals that the stem cell quiescent state is composed of two distinct phases, G0 and GAlert; stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway.

    • Joseph T. Rodgers
    • Katherine Y. King
    • Thomas A. Rando
    Research
    Nature
    Volume: 510, P: 393-396

  • Open scholarship has transformed research, and introduced a host of new terms in the lexicon of researchers. The ‘Framework for Open and Reproducible Research Teaching’ (FORRT) community presents a crowdsourced glossary of open scholarship terms to facilitate education and effective communication between experts and newcomers.

    • Sam Parsons
    • Flávio Azevedo
    • Balazs Aczel
    Comments & Opinion
    Nature Human Behaviour
    Volume: 6, P: 312-318

  • Cataloging microbial genomes from Earth’s environments expands the known phylogenetic diversity of bacteria and archaea.

    • Stephen Nayfach
    • Simon Roux
    • Emiley A. Eloe-Fadrosh
    ResearchOpen Access
    Nature Biotechnology
    Volume: 39, P: 499-509