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Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Pneumococcal carriage in the upper respiratory tract is an important determinant of influenza severity. Jochems et al. use human systems analysis to show that influenza-induced inflammation increases bacterial burden in the nasal cavity with implications for secondary bacterial pneumonia.

Simon P. Jochems
Fernando Marcon
Daniela M. Ferreira
Research29 Oct 2018
Nature Immunology

Volume: 19, P: 1299-1308
Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

Clinical management of COVID-19 in resource-poor settings has distinct challenges and detailed patient characterisation is needed. Here, the authors describe the clinical and immunological profiles of patients at a hospital in Malawi with confirmed and suspected COVID-19.

Ben Morton
Kayla G. Barnes
Kondwani C. Jambo
ResearchOpen Access11 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Using a Streptococcus pneumoniae human challenge model, the authors here show that baseline nasal microbiota profiles are associated with pneumococcal acquisition and density, independent of live-attenuated influenza vaccine (LAIV) administration, and with mucosal cytokine responses to LAIV.

Wouter A. A. de Steenhuijsen Piters
Simon P. Jochems
Debby Bogaert
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

Maini and colleagues used bronchoalveolar lavage (BAL) samples from the lower respiratory tract of healthy donors obtained before the COVID-19 pandemic to show airway-resident cross-reactive T cells are present in pre-pandemic BAL, and correlated with the strength of human coronavirus immunity

Mariana O. Diniz
Elena Mitsi
Mala K. Maini
ResearchOpen Access29 Aug 2022
Nature Immunology

Volume: 23, P: 1324-1329
The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash

Elissavet Nikolaou
Esther L. German
Daniela M. Ferreira
ResearchOpen Access14 Sept 2021
Scientific Reports

Volume: 11, P: 1-9

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Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash

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